V Lakshmipriya, Jayaraman MonishaRita, Kannan Kavitha, Priya Lakshmi
Pathology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 May 11;16(5):e60121. doi: 10.7759/cureus.60121. eCollection 2024 May.
The development of pleural effusion in chronic myeloid leukemia (CML) is not well-understood and rarely documented in literature. Extramedullary involvement (EMI), which occurs in about 10% of CML cases, typically affects lymph nodes and the spleen. Instances of extensive infiltration of leukemic cells into the pleura are infrequently reported in CML. Here, we report a case of 41-year-old man experiencing significant bilateral pleural effusion with leukemic infiltration during the blast crisis (BC) phase of refractory CML. Examination of the pleural fluid revealed cells with morphological characteristics of myeloblasts. Although very rare, pleural leukemic infiltration should be considered as a cause of pleural effusion in patients with CML, especially in the BC phase.
慢性髓系白血病（CML）中胸腔积液的发生机制尚不清楚，且在文献中鲜有记载。髓外浸润（EMI）约发生在10%的CML病例中，通常累及淋巴结和脾脏。CML中白血病细胞广泛浸润胸膜的情况鲜有报道。在此，我们报告一例41岁男性，在难治性CML的急变期（BC）出现大量双侧胸腔积液伴白血病浸润。胸腔积液检查发现具有原粒细胞形态特征的细胞。尽管非常罕见，但在CML患者中，尤其是在BC期，应考虑胸膜白血病浸润是胸腔积液的一个原因。
