Anbardar Mohammad Hossein, Rahimizadeh Nadia
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran J Pathol. 2024 Winter;19(1):59-66. doi: 10.30699/IJP.2023.1999329.3090. Epub 2021 Dec 15.
BACKGROUND & OBJECTIVE: Colorectal cancer is the second reason for cancer-associated death. The prognosis of the malignancy is defined by TNM scoring. However, tumor grading, lymphovascular invasion, perineural invasion, and tumor buddings may affect its prognosis. This study aimed to assess the prognostic and histologic impact of tumor budding in colorectal adenocarcinoma.
This study is a retrospective cohort of 192 patients with colorectal adenocarcinoma. All four stages of colorectal adenocarcinoma patients were included, but the patients in stages I and II were also analyzed separately. We used pathology reports to extract the histopathologic data. The prognostic values were extracted by calling the patients.
Less than half of the patients were in stages I and II of the disease. According to our analysis, tumor extension and lymphovascular invasion were correlated with tumor budding count in patients in stages I and II, and lymphovascular invasion, tumor grade, tumor stage, lymph node involvement, tumor extension, tumor site, metastasis, and five-year survival were correlated with tumor budding within all stages.
It is recommended that tumor budding count should be assessed and reported in pathology reports of adenocarcinomas due to its high correlation with poor prognosis.
结直肠癌是癌症相关死亡的第二大原因。恶性肿瘤的预后由TNM分期确定。然而，肿瘤分级、淋巴管侵犯、神经周围侵犯和肿瘤芽生可能影响其预后。本研究旨在评估肿瘤芽生在结直肠腺癌中的预后及组织学影响。
本研究是一项对192例结直肠腺癌患者的回顾性队列研究。纳入了所有四期结直肠腺癌患者，但对I期和II期患者也分别进行了分析。我们利用病理报告提取组织病理学数据。通过随访患者提取预后值。
不到一半的患者处于疾病的I期和II期。根据我们的分析，肿瘤浸润和淋巴管侵犯与I期和II期患者的肿瘤芽生计数相关，而淋巴管侵犯、肿瘤分级、肿瘤分期、淋巴结受累、肿瘤浸润、肿瘤部位、转移和五年生存率与所有阶段的肿瘤芽生相关。
由于肿瘤芽生计数与不良预后高度相关，建议在腺癌病理报告中评估并报告肿瘤芽生计数。
