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[高炎症免疫反应综合征PIMS-TS]

[Hyperinflammatory immune response syndrome PIMS-TS].

作者信息

Müller-Groen Magdalena, Flury Gian

机构信息

Departement ANIR, Institut für Anästhesiologie, Kantonsspital Graubünden, Chur.

Medizinische Klinik, Ospidal CSEB, Scuol, Switzerland,

出版信息

Praxis (Bern 1994). 2024 May;113(5):142-145. doi: 10.23785/PRAXIS.2024.05.006.

Abstract

PIMS-TS is a rare hyperinflammatory immune response syndrome, usually occurring two to six weeks after SARS-CoV-2 infection, which mainly affects schoolchildren and is often associated with the need for intensive care (2). The most common clinical signs are high fever, gastrointestinal symptoms such as abdominal pain, vomiting and diarrhea, cardiovascular dysfunction (impaired LVEF, hypotension, shock) and neurological symptoms such as headache and encephalopathy (1, 2, 4). The definition criteria include various clinical and laboratory parameters, which vary slightly depending on the authors (4, 6, 7). With intensive care treatment with circulatory support and administration of methylprednisolone, mortality and long-term consequences remain low.

摘要

儿童多系统炎症综合征(PIMS-TS)是一种罕见的高炎症免疫反应综合征,通常在感染新型冠状病毒2(SARS-CoV-2)后两至六周出现,主要影响学龄儿童,且常伴有重症监护需求(2)。最常见的临床症状是高热、腹痛、呕吐和腹泻等胃肠道症状、心血管功能障碍(左心室射血分数降低、低血压、休克)以及头痛和脑病等神经症状(1、2、4)。定义标准包括各种临床和实验室参数,不同作者的标准略有差异(4、6、7)。通过循环支持和甲基强的松龙给药的重症监护治疗,死亡率和长期后果仍然较低。

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