Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.
Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India. Correspondence to: Dr Aishwarya Venkataraman, Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, 12A Nageswara Road, Nungambakkam, Chennai 600 034, India.
Indian Pediatr. 2020 Nov 15;57(11):1010-1014. doi: 10.1007/s13312-020-2025-1. Epub 2020 Aug 6.
We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS).
We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020.
We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths.
Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.
我们描述了符合 SARS-CoV-2 相关儿童多系统炎症综合征病例定义（PIMS-TS）的儿童的人口统计学、临床和实验室检查结果以及治疗和转归。
我们分析了 2020 年 5 月 4 日至 7 月 8 日期间 8 周内出现 PIMS-TS 的儿童的临床和实验室检查结果。
我们报告了 19 名符合 PIMS-TS 病例定义的儿童，中位年龄为 6 岁（IQR：13 个月-16 岁）。他们均有发热，多器官受累（79%）、黏膜皮肤受累（74%）、心血管症状（63%）和胃肠道症状（42%）是其他特征。所有患儿的 C-反应蛋白水平升高，大多数患儿有凝血功能障碍的证据；12 名（63%）患儿需要入住重症监护病房，6 名（31.5%）患儿给予血管活性药物。无死亡病例。
患有 PIMS-TS 的儿童表现出广泛的症状和体征。本系列中较少儿童有冠状动脉异常，且 RT-PCR 阳性率较低，而 SARS-CoV-2 抗体阳性率较高。
