Department of Biochemistry, University of the Incarnate Word, 4301 Broadway, San Antonio, TX 78209, U.S.A.
Department of Biological and Chemical Sciences, The University of the West Indies, Cave Hill Campus, Bridgetown Barbados BB11000, Barbados.
Essays Biochem. 2024 Oct 3;68(2):135-146. doi: 10.1042/EBC20230088.
Malate dehydrogenase (MDH) is an essential enzyme in the tricarboxylic acid cycle that functions in cellular respiration and redox homeostasis. Recent studies indicate that MDH facilitates metabolic plasticity in tumor cells, catalyzing the formation of an oncometabolite, contributing to altered epigenetics, and maintaining redox capacity to support the rewired energy metabolism and biosynthesis that enables cancer progression. This minireview summarizes current findings on the unique supporting roles played by MDH in human cancers and provides an update on targeting MDH in cancer chemotherapy.
苹果酸脱氢酶（MDH）是三羧酸循环中的一种必需酶，参与细胞呼吸和氧化还原稳态。最近的研究表明，MDH 促进肿瘤细胞的代谢可塑性，催化形成致癌代谢物，导致表观遗传学改变，并维持氧化还原能力以支持重新连接的能量代谢和生物合成，从而促进癌症进展。本文综述了 MDH 在人类癌症中发挥的独特支持作用的最新发现，并介绍了靶向 MDH 进行癌症化疗的最新进展。
