Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
Department of Medicine, State University of Maringá, Maringá, Paraná, Brazil.
Expert Rev Mol Diagn. 2024 Jun;24(6):525-531. doi: 10.1080/14737159.2024.2367466. Epub 2024 Jun 17.
A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.
The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in ; rs2292151 in ; rs1758566 in ; rs1800629 in , and rs1800795 in with the severity of Covid-19.
A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil. In total, 300 patients were genotyped for the SNPs, 150 with the non-severe form of the disease and 150 with severe/critical form.
The T/T genotype of in recessive model shows 58% of protection against severe/critical Covid-19; as well as the genotypes G/A+A/A of in dominant model with 60% of protection, and in a codominant model G/A with 57% and A/A with 71% of protection against severe/critical Covid-19. Comparing severe and critical cases, the T/C genotype of in the codominant model and TC+C/C in the dominant model showed twice the risk of critical Covid-19.
We can conclude that rs3775291, rs2292151 and rs1758566 can influence the COVID-19 severity.
在 2019 年冠状病毒病（Covid-19）的重症患者中观察到一种独特的表型，其特征是干扰素（IFN）I 型反应严重受损，炎症反应加剧。
本研究旨在探讨五个与免疫反应相关的基因中的单核苷酸多态性（SNPs），rs3775291 在 、rs2292151 在 、rs1758566 在 、rs1800629 在 和 rs1800795 在 与 Covid-19 严重程度的可能相关性。
这是一项横断面研究，由巴西的两家公立医院对诊断为 Covid-19 的非重症和重症/危重症患者进行研究。共有 300 例患者进行了 SNPs 基因分型，其中 150 例为非重症疾病患者，150 例为重症/危重症患者。
在隐性模型中， 中的 T/T 基因型对重症/危重症 Covid-19 有 58%的保护作用；在显性模型中， 中的 G/A+A/A 基因型有 60%的保护作用，在共显性模型中，G/A 有 57%和 A/A 有 71%的保护作用。比较重症和危重症病例，在共显性模型中 中的 T/C 基因型和在显性模型中 TC+C/C 基因型显示出危重症 Covid-19 的风险增加两倍。
我们可以得出结论，rs3775291、rs2292151 和 rs1758566 可以影响 COVID-19 的严重程度。
