巴西南部、、基因多态性与新冠肺炎严重程度的相关性研究。

Association between polymorphisms in , and genes and covid-19 severity in Southern Brazil.

机构信息

Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.

Department of Medicine, State University of Maringá, Maringá, Paraná, Brazil.

出版信息

Expert Rev Mol Diagn. 2024 Jun;24(6):525-531. doi: 10.1080/14737159.2024.2367466. Epub 2024 Jun 17.

DOI:10.1080/14737159.2024.2367466

PMID:38864429

Abstract

BACKGROUND

A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.

OBJECTIVE

The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in ; rs2292151 in ; rs1758566 in ; rs1800629 in , and rs1800795 in with the severity of Covid-19.

METHODS

A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil. In total, 300 patients were genotyped for the SNPs, 150 with the non-severe form of the disease and 150 with severe/critical form.

RESULTS

The T/T genotype of in recessive model shows 58% of protection against severe/critical Covid-19; as well as the genotypes G/A+A/A of in dominant model with 60% of protection, and in a codominant model G/A with 57% and A/A with 71% of protection against severe/critical Covid-19. Comparing severe and critical cases, the T/C genotype of in the codominant model and TC+C/C in the dominant model showed twice the risk of critical Covid-19.

CONCLUSION

We can conclude that rs3775291, rs2292151 and rs1758566 can influence the COVID-19 severity.

摘要

背景

在 2019 年冠状病毒病（Covid-19）的重症患者中观察到一种独特的表型，其特征是干扰素（IFN）I 型反应严重受损，炎症反应加剧。

目的

本研究旨在探讨五个与免疫反应相关的基因中的单核苷酸多态性（SNPs），rs3775291 在、rs2292151 在、rs1758566 在、rs1800629 在和 rs1800795 在与 Covid-19 严重程度的可能相关性。

方法

这是一项横断面研究，由巴西的两家公立医院对诊断为 Covid-19 的非重症和重症/危重症患者进行研究。共有 300 例患者进行了 SNPs 基因分型，其中 150 例为非重症疾病患者，150 例为重症/危重症患者。

结果

在隐性模型中，中的 T/T 基因型对重症/危重症 Covid-19 有 58%的保护作用；在显性模型中，中的 G/A+A/A 基因型有 60%的保护作用，在共显性模型中，G/A 有 57%和 A/A 有 71%的保护作用。比较重症和危重症病例，在共显性模型中中的 T/C 基因型和在显性模型中 TC+C/C 基因型显示出危重症 Covid-19 的风险增加两倍。