Kenyon C J, McKeever A, Oliver J A, Henderson I W
Gen Comp Endocrinol. 1985 Apr;58(1):93-100. doi: 10.1016/0016-6480(85)90140-6.
Plasma ions and cortisol levels were measured sequentially during the adaptation of European eels (Anguilla anguilla) from fresh water (FW) to sea water (SW). The importance of the renin-angiotensin system in the regulation of this adaptation was assessed using captopril (SQ14225, an inhibitor of angiotensin I-converting enzyme). The effects of captopril on renal function in FW- and SW-adapted trout were also examined. During the first 5 hr in sea water, plasma levels of cortisol in eels increased threefold, plasma sodium rose steadily from 137 to 156 mmol/l and plasma potassium fell from 2.1 to 1.6 mmol/l. In contrast, captopril-treated eels when adapted to sea water had plasma cortisol levels twice those of controls. Captopril treatment did not affect the electrolyte responses to seawater adaptation. Captopril injected into eels which were fully adapted to and wholly maintained in sea water had no effect on plasma levels of cortisol, sodium, and potassium. Plasma cortisol was 30% lower in freshwater eels 2 hr after an injection of captopril but plasma sodium and potassium levels were unchanged. In both FW- and SW-adapted trout, captopril infusions doubled the glomerular filtration and urine production rates and the tubular transport maxima for glucose without changes in plasma composition.
在欧洲鳗鲡（Anguilla anguilla）从淡水（FW）适应海水（SW）的过程中，依次测量了血浆离子和皮质醇水平。使用卡托普利（SQ14225，一种血管紧张素I转换酶抑制剂）评估了肾素 - 血管紧张素系统在这种适应调节中的重要性。还研究了卡托普利对适应淡水和海水的鳟鱼肾功能的影响。在海水中的最初5小时内，鳗鲡的血浆皮质醇水平增加了两倍，血浆钠从137 mmol/l稳步上升至156 mmol/l，血浆钾从2.1 mmol/l降至1.6 mmol/l。相比之下，经卡托普利处理的鳗鲡在适应海水时，其血浆皮质醇水平是对照组的两倍。卡托普利处理不影响对海水适应的电解质反应。向完全适应并一直饲养在海水中的鳗鲡注射卡托普利，对血浆皮质醇、钠和钾水平没有影响。注射卡托普利2小时后，淡水鳗鲡的血浆皮质醇降低30%，但血浆钠和钾水平未改变。在适应淡水和海水的鳟鱼中，输注卡托普利使肾小球滤过率和尿生成率以及葡萄糖的肾小管转运最大值增加了一倍，而血浆成分没有变化。
