Carrick S, Balment R J
Gen Comp Endocrinol. 1983 Sep;51(3):423-33. doi: 10.1016/0016-6480(83)90059-x.
Drinking behaviour and its possible regulation by the renin-angiotensin system (RAS) has been examined in the euryhaline flounder. Fluid intake was greater in seawater (SW)-adapted than freshwater (FW)-adapted fish, the latter having significantly lower plasma sodium, chloride, and osmotic concentrations. Oesophageal cannulation in SW-adapted fish resulted in further elevation of drinking rates, which increased proportionally with progressive body water loss as measured by the fall in body weight and rise in plasma tonicity. The influence of the RAS on drinking in SW-adapted fish was examined in animals with an intact gastrointestinal tract. Fluid intake fell markedly following administration of the converting enzyme inhibitor, Captopril. Infusions of angiotensin I (AI) and angiotensin II (AII) induced dose-related increments in the rate of drinking. The increased drinking in response to AI was inhibited, however, by the simultaneous administration of Captopril. The results are consistent with the presence in the flounder of the major elements of the RAS, including AI, AII, and a converting enzyme-like substance. The RAS appears to play an important regulatory role in the adaptative drinking behaviour associated with migration of euryhaline teleosts between FW and SW.
已经在广盐性比目鱼中研究了饮水行为及其可能受肾素-血管紧张素系统（RAS）的调节。适应海水（SW）的鱼比适应淡水（FW）的鱼饮水量更大，后者的血浆钠、氯和渗透压浓度显著更低。对适应SW的鱼进行食管插管导致饮水速率进一步升高，随着体重下降和血浆张力升高所测量的渐进性身体失水，饮水速率成比例增加。在具有完整胃肠道的动物中研究了RAS对适应SW的鱼饮水的影响。给予转化酶抑制剂卡托普利后，液体摄入量显著下降。输注血管紧张素I（AI）和血管紧张素II（AII）可诱导饮水速率出现剂量相关的增加。然而，同时给予卡托普利可抑制对AI的饮水增加反应。这些结果与比目鱼中存在RAS的主要成分一致，包括AI、AII和一种类似转化酶的物质。RAS似乎在广盐性硬骨鱼在淡水和海水之间洄游相关的适应性饮水行为中发挥重要的调节作用。
