Tierney M L, Luke G, Cramb G, Hazon N
Gatty Marine Laboratory, School of Biological and Medical Sciences, University of St. Andrews, Fife, United Kingdom.
Gen Comp Endocrinol. 1995 Oct;100(1):39-48. doi: 10.1006/gcen.1995.1130.
The role of the renin-angiotensin system (RAS) in the control of blood pressure and drinking was investigated in fresh water (FW)- and seawater (SW)-adapted eels, Anguilla anguilla, by comparing the effects of pharmacological manipulation through the use of papaverine (stimulator) and captopril (inhibitor) on the endogenous system. In SW eels basal blood pressure levels were lower (23.3 +/- 0.8 mm Hg) with correspondingly higher basal drinking rates (0.51 +/- 0.07 ml/kg/hr) and plasma AII concentrations (32.89 +/- 4.19 fmol/ml) compared to FW eels (33.8 +/- 1.3 mm Hg, 0.06 +/- 0.02 ml/kg/hr, 9.72 +/- 0.60 fmol/ml, respectively). In FW eels papaverine caused immediate hypotension with full recovery, decrease in plasma osmolality, and increase in drinking rate and plasma AII concentration, but in SW eels, hypotension with full recovery and an increase in plasma osmolality, drinking rate, and plasma AII concentration occurred. In FW eels captopril had no effect on the parameters measured, but in SW eels it caused a sustained decrease in blood pressure and a decline in the basal drinking rate and plasma AII concentration. Papaverine was also administered 15 min after captopril. In FW eels this manipulation caused hypotension only after the papaverine injection, followed by a partial recovery. Osmolality was unaffected, the previously observed papaverine-induced dipsogenic response was blocked, and the rise in plasma AII concentrations was smaller than with papaverine only. In SW eels there was an immediate hypotension after captopril administration with full recovery.(ABSTRACT TRUNCATED AT 250 WORDS)
通过比较使用罂粟碱（刺激剂）和卡托普利（抑制剂）进行药理操作对内源系统的影响，研究了肾素 - 血管紧张素系统（RAS）在控制淡水（FW）和海水（SW）适应的欧洲鳗鲡（Anguilla anguilla）血压和饮水方面的作用。与FW鳗鲡（分别为33.8±1.3 mmHg、0.06±0.02 ml/kg/hr、9.72±0.60 fmol/ml）相比，SW鳗鲡的基础血压水平较低（23.3±0.8 mmHg），相应的基础饮水率较高（0.51±0.07 ml/kg/hr），血浆血管紧张素II（AII）浓度较高（32.89±4.19 fmol/ml）。在FW鳗鲡中，罂粟碱导致立即出现低血压并完全恢复，血浆渗透压降低，饮水率和血浆AII浓度增加，但在SW鳗鲡中，出现低血压并完全恢复，同时血浆渗透压、饮水率和血浆AII浓度增加。在FW鳗鲡中，卡托普利对所测参数无影响，但在SW鳗鲡中，它导致血压持续下降，基础饮水率和血浆AII浓度降低。在卡托普利给药15分钟后也给予罂粟碱。在FW鳗鲡中，这种操作仅在注射罂粟碱后导致低血压，随后部分恢复。渗透压未受影响，先前观察到的罂粟碱诱导的致渴反应被阻断，血浆AII浓度的升高小于仅使用罂粟碱时。在SW鳗鲡中，卡托普利给药后立即出现低血压并完全恢复。（摘要截断于250字）
