Equipe Labellisée la Ligue Contre le Cancer, Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France.
J Cell Biol. 2024 Aug 5;223(8). doi: 10.1083/jcb.202401112. Epub 2024 Jun 12.
During aging and in some contexts, like embryonic development, wound healing, and diseases such as cancer, senescent cells accumulate and play a key role in different pathophysiological functions. A long-held belief was that cellular senescence decreased normal cell functions, given the loss of proliferation of senescent cells. This view radically changed following the discovery of the senescence-associated secretory phenotype (SASP), factors released by senescent cells into their microenvironment. There is now accumulating evidence that cellular senescence also promotes gain-of-function effects by establishing, reinforcing, or changing cell identity, which can have a beneficial or deleterious impact on pathophysiology. These effects may involve both proliferation arrest and autocrine SASP production, although they largely remain to be defined. Here, we provide a historical overview of the first studies on senescence and an insight into emerging trends regarding the effects of senescence on cell identity.
在衰老过程中，以及在某些情况下，如胚胎发育、伤口愈合和癌症等疾病，衰老细胞会积累并在不同的病理生理功能中发挥关键作用。长期以来，人们一直认为，由于衰老细胞失去了增殖能力，细胞衰老降低了正常细胞的功能。这种观点在发现衰老相关分泌表型（SASP）后发生了根本性的改变，SASP 是衰老细胞释放到其微环境中的因子。现在有越来越多的证据表明，细胞衰老也可以通过建立、加强或改变细胞特性来促进功能获得效应，这可能对病理生理学产生有益或有害的影响。这些效应可能既涉及增殖停滞，也涉及自分泌 SASP 的产生，尽管它们在很大程度上仍有待定义。在这里，我们提供了关于衰老的最初研究的历史概述，并深入了解了衰老对细胞特性影响的新兴趋势。
