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Sirtuin1（sirt1）调节糖酵解途径，降低食管鳞癌对顺铂化疗的敏感性。

Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma.

机构信息

Gastrointestinal Surgery Department, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.

Clinical Nutrition Department, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.

出版信息

Cancer Biol Ther. 2024 Dec 31;25(1):2365449. doi: 10.1080/15384047.2024.2365449. Epub 2024 Jun 12.

DOI:10.1080/15384047.2024.2365449
PMID:38865161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11174053/
Abstract

We aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse tumor model. The tumor volume was then detected. sirt1 was over-expressed significantly in ESCC patients and cells. Moreover, sirt1 knockdown raised ESCC sensitivity to cisplatin. Besides, glycolysis was associated with ESCC cell chemotherapy resistance to cisplatin. Furthermore, sirt1 increased ESCC cells' cisplatin chemosensitivity through HK2. Sirt1 enhanced ESCC chemosensitivity to cisplatin. Overall, these findings suggested that sirt1 knockdown regulated the glycolysis pathway and raised the ESCC chemotherapeutic sensitivity.

摘要

我们旨在评估去乙酰化酶 1（sirt1）对食管鳞癌（ESCC）顺铂化疗敏感性的影响。我们使用 ESCC 细胞消融 sirt1 建立了异种移植小鼠肿瘤模型，然后检测了肿瘤体积。sirt1 在 ESCC 患者和细胞中显著过表达。此外，sirt1 敲低可提高 ESCC 对顺铂的敏感性。此外，糖酵解与 ESCC 细胞对顺铂的化疗耐药性有关。此外，sirt1 通过 HK2 增加 ESCC 细胞对顺铂的化疗敏感性。总的来说，这些发现表明 sirt1 敲低可调节糖酵解途径，提高 ESCC 的化疗敏感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/9fc15b3382f2/KCBT_A_2365449_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/4cbc3806adce/KCBT_A_2365449_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/cfe43327d637/KCBT_A_2365449_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/232252288474/KCBT_A_2365449_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/8239a2d8842b/KCBT_A_2365449_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/15850e8978fc/KCBT_A_2365449_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/fdf16b589c0d/KCBT_A_2365449_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/9fc15b3382f2/KCBT_A_2365449_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/4cbc3806adce/KCBT_A_2365449_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/cfe43327d637/KCBT_A_2365449_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/232252288474/KCBT_A_2365449_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/8239a2d8842b/KCBT_A_2365449_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/15850e8978fc/KCBT_A_2365449_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/fdf16b589c0d/KCBT_A_2365449_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f7/11174053/9fc15b3382f2/KCBT_A_2365449_F0007_OC.jpg

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