Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
J Infect Dev Ctries. 2024 May 30;18(5):822-825. doi: 10.3855/jidc.18269.
Multisystem inflammatory syndrome in children (MIS-C) is a serious hyperinflammatory condition associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Usually, the diagnosis of MIS-C is made by criteria defined by international organizations, which include specific clinical features, laboratory findings, and evidence of SARS-CoV-2 infection. We hereby present a case series of three children. The objective of this case series, involving chart review of medical records of children admitted with MIS-C, is to emphasize that the features of MIS-C may overlap with other conditions.
Three children were presented with MIS-C based on World Health Organization (WHO) criteria and given treatment for the same. However, due to persistent symptoms, they were further worked up and diagnosed to have underlying bacterial infections which included liver abscess, enteric fever, or urinary tract infection.
The criteria for MIS-C may overlap with other conditions, particularly bacterial infection that may lead to overdiagnosis of MIS-C. Therefore, one should be very careful in making an MIS-C diagnosis and other differential diagnoses should be considered when the symptoms persist or worsen.
儿童多系统炎症综合征（MIS-C）是一种与严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）感染相关的严重炎症性疾病。通常，MIS-C 的诊断是通过国际组织定义的标准进行的，包括特定的临床特征、实验室发现和 SARS-CoV-2 感染的证据。我们在此介绍了三例儿童病例。本病例系列研究，通过对患有 MIS-C 的儿童的病历进行图表回顾，旨在强调 MIS-C 的特征可能与其他疾病重叠。
根据世界卫生组织（WHO）标准，有三名儿童被诊断为 MIS-C，并接受了相同的治疗。然而，由于持续存在症状，他们进一步进行了检查，被诊断为存在潜在的细菌感染，包括肝脓肿、伤寒或尿路感染。
MIS-C 的标准可能与其他疾病重叠，特别是细菌感染，这可能导致 MIS-C 的过度诊断。因此，在做出 MIS-C 诊断时应非常小心，如果症状持续或恶化，应考虑其他鉴别诊断。
