Fixed ratio combination of propranolol and bendrofluazide in the treatment of hypertension.

The combination of beta adrenoceptor blocker, i.e. propranolol (80 mg) and a diuretic, i.e. bendrofluazide (2.5 mg) in a single capsule (Inderetic) produced an effective control of blood pressure in 12 out of 13 patients with mild and moderately severe hypertension in this single-blind study. Treatment for 12 weeks did not produce any changes in biochemical parameters and no change in ECG, except that a significant decrease in heart rate was observed. No serious side-effects were observed.