Agrawal R L, Alliott R J, George M, Gomez G, Trafford J A, Jequier P W, Lishman J D, Turner J R, Baber N S, Dawes P M
J R Coll Gen Pract. 1979 Oct;29(207):602-6.
In 101 hypertensive patients, the effects of a combination of propranolol and bendrofluazide were compared with those of each drug alone. After an introductory period with a placebo, the patients received, in a double-blind randomized trial, propranolol 80 mg twice a day, bendrofluazide 2.5 mg twice a day, or both drugs together twice daily. The combination produced significantly greater reductions in lying, standing, and post-exercise systolic and diastolic blood pressure than either drug separately. Side-effects were minimal and the combination was well accepted by patients.
在101名高血压患者中，对普萘洛尔和苄氟噻嗪联合用药的效果与单独使用每种药物的效果进行了比较。在服用安慰剂的导入期后，患者在双盲随机试验中接受以下治疗：每天两次，每次80毫克普萘洛尔；每天两次，每次2.5毫克苄氟噻嗪；或两种药物每天一起服用两次。与单独使用任何一种药物相比，联合用药在卧位、立位及运动后收缩压和舒张压的降低幅度上均显著更大。副作用极小，患者对联合用药的接受度良好。
