Stewart J R
Cancer Res. 1984 Oct;44(10 Suppl):4902s-4904s.
The biological rationale for hyperthermia and radiation is strong, initial results in superficial tumor sites have established efficacy in human cancer, and deep tumor sites are beginning to yield to our efforts at deep regional heating. Major thrusts of new clinical research should go toward improved equipment and defining techniques with existing devices, which can lead us into definitive Phase III trials to assess the role of regional hyperthermia in primary multimodality management of cancer. Detailed thermometry is an absolute requirement for all future clinical studies. Invasive techniques to achieve deep hyperthermia are under investigation and may prove to be useful. Whole-body hyperthermia with radiation and/or chemotherapy has been less well studied in the laboratory than has local hyperthermia, and studies to show clinical efficacy in humans are lacking.
热疗与放疗的生物学原理依据充分，浅表肿瘤部位的初步结果已证实其对人类癌症有效，而深部肿瘤部位也开始因我们在深部区域加热方面的努力而取得进展。新临床研究的主要方向应是改进设备以及利用现有设备确定技术，这能引领我们开展确定性的III期试验，以评估区域热疗在癌症主要多模式治疗中的作用。详细的体温测量对于所有未来的临床研究而言是绝对必要的。用于实现深部热疗的侵入性技术正在研究中，可能会证明是有用的。与局部热疗相比，实验室对放疗和/或化疗联合全身热疗的研究较少，且缺乏在人体中显示临床疗效的研究。
