Matsuda T
Gan No Rinsho. 1986 Aug;32(10):1095-9.
The expectation that hyperthermia would be effective in the treatment of cancer is attributable to a theoretical viewpoint based upon biological studies. Cancer cells, which characteristically are hypoxic with poor nutrition and low pH, are sensitive to temperatures over 42.5 degrees C. This is the theoretical basis which assures the effectiveness of hyperthermia when used in combination with radiation therapy. Previous clinical studies have shown that a combination hyperthermia and radiation therapy is an effective treatment for superficial tumors, thus expanding the range of cancer therapy. When used for deeply seated cancer, this combination enhances the efficiency of therapy. It is, however, necessary to improve the heating techniques and methods of thermometry. Fundamental studies are now being actively pursued in respect of combined hyperthermia and chemotherapy. However, inadequacy of clinical material hinders evaluation. The combination of whole-body hyperthermia with anti-cancer agents presents so far, unsolved problems, such as determination of applicable anatomical regions and prevention of complications.
人们期望热疗能有效治疗癌症，这归因于基于生物学研究的理论观点。癌细胞的特征是缺氧、营养差且pH值低，对42.5摄氏度以上的温度敏感。这就是热疗与放射治疗联合使用时确保其有效性的理论基础。先前的临床研究表明，热疗与放射治疗联合是治疗浅表肿瘤的有效方法，从而扩大了癌症治疗的范围。当用于深部癌症时，这种联合可提高治疗效率。然而，有必要改进加热技术和测温方法。目前正在积极开展热疗与化疗联合的基础研究。然而，临床资料不足阻碍了评估。全身热疗与抗癌药物的联合目前存在一些尚未解决的问题，如适用解剖区域的确定和并发症的预防。
