Department of Biological Sciences and Biomedical Engineering, Ulsan National Institute of Science and Technology Ulsan, Republic of Korea.
Biomedical Engineering, Ulsan National Institute of Science and Technology Ulsan, Republic of Korea.
J Photochem Photobiol B. 2024 Aug;257:112949. doi: 10.1016/j.jphotobiol.2024.112949. Epub 2024 Jun 2.
Large scale outbreaks of infectious respiratory disease have repeatedly plagued the globe over the last 100 years. The scope and strength of the outbreaks are getting worse as pathogenic RNA viruses are rapidly evolving and highly evasive to vaccines and anti-viral drugs. Germicidal UV-C is considered as a robust agent to disinfect RNA viruses regardless of their evolution. While genomic damage by UV-C has been known to be associated with viral inactivation, the precise relationship between the damage and inactivation remains unsettled as genomic damage has been analyzed in small areas, typically under 0.5 kb. In this study, we assessed genomic damage by the reduced efficiency of reverse transcription of regions of up to 7.2 kb. Our data seem to indicate that genomic damage was directly proportional to the size of the genome, and a single hit of damage was sufficient for inactivation of RNA viruses. The high efficacy of UV-C is already effectively adopted to inactivate airborne RNA viruses.
在过去的 100 年中，大规模爆发的传染性呼吸道疾病反复困扰着全球。由于致病 RNA 病毒迅速进化，并且对疫苗和抗病毒药物高度逃避，疫情的范围和强度正在恶化。杀菌紫外线-C 被认为是一种强大的消毒剂，可以消灭 RNA 病毒，无论其如何进化。虽然人们已经知道 UV-C 的基因组损伤与病毒失活有关，但由于基因组损伤仅在 0.5kb 以下的小区域内进行了分析，因此损伤与失活之间的精确关系仍未确定。在这项研究中，我们评估了长达 7.2kb 区域的逆转录效率降低所导致的基因组损伤。我们的数据似乎表明，基因组损伤与基因组的大小成正比，单个损伤足以使 RNA 病毒失活。紫外线-C 的高效性已经被有效地用于消灭空气中的 RNA 病毒。
