Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, China; Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang 453002, China; International Joint Research Laboratory for Psychiatry and Neuroscience of Henan of Xinxiang Medical University, Xinxiang 453002, China; Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, Xinxiang 453002, China.
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, China.
Asian J Psychiatr. 2024 Aug;98:104106. doi: 10.1016/j.ajp.2024.104106. Epub 2024 Jun 6.
In patients with schizophrenia, there is abnormal regional functional synchrony. However, whether it also in patients with adolescent-onset schizophrenia (AOS) remains unclear. The goal of this study was to analyze the regional homogeneity (ReHo) of resting functional magnetic resonance imaging to explore the functional abnormalities of the brain in patients with AOS.
The study included 107 drug-naive first-episode AOS patients and 67 healthy, age, sex, and education-matched controls using resting-state functional magnetic resonance imaging scans. The ReHo method was used to analyze the imaging dataset.
Compared with the control group, the ReHo values of the right inferior frontal gyrus orbital part, right middle frontal gyrus (MFG.R), left inferior parietal, but supramarginal and angular gyri, and left precentral gyrus (PreCG.L) were significantly increased and the ReHo value of the left posterior cingulate cortex/anterior cuneiform lobe was significantly decreased in schizophrenia patients. ROC analysis showed that the ReHo values of the MFG.R and PreCG.L might be regarded as potential markers in helping to identify patients. Furthermore, the PANSS scores in the patient group and the ReHo values showed a positive correlation between MFG.R ReHo values and general scores.
Our results suggested that AOS patients had ReHo abnormalities. The ReHo values of these abnormal regions may serve as potential imaging biomarkers for the identification of AOS patients.
精神分裂症患者存在区域性功能同步异常。然而，青少年起病的精神分裂症（AOS）患者是否也存在这种情况尚不清楚。本研究旨在通过分析静息态功能磁共振成像的局部一致性（ReHo），探讨 AOS 患者的脑功能异常。
本研究纳入了 107 例未经药物治疗的首发 AOS 患者和 67 例年龄、性别、教育程度相匹配的健康对照者，使用静息态功能磁共振成像扫描。采用 ReHo 方法对影像数据集进行分析。
与对照组相比，精神分裂症患者右侧额下回眶部、右侧额中回（MFG.R）、左侧顶下小叶、但缘上回和角回以及左侧中央前回（PreCG.L）的 ReHo 值显著升高，而左侧后扣带回/楔前叶的 ReHo 值显著降低。ROC 分析显示，MFG.R 和 PreCG.L 的 ReHo 值可能可作为潜在的标志物，有助于识别患者。此外，患者组的 PANSS 评分与 MFG.R 的 ReHo 值呈正相关。
本研究结果表明，AOS 患者存在 ReHo 异常。这些异常区域的 ReHo 值可能成为识别 AOS 患者的潜在影像学生物标志物。
