Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St, Hobart, TAS 7000, Australia.
Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St, Hobart, TAS 7000, Australia.
Trends Neurosci. 2024 Aug;47(8):569-570. doi: 10.1016/j.tins.2024.06.001. Epub 2024 Jun 11.
Neurons have high energy demands. In a recent study, Looser et al. identified oligodendrocyte Kir4.1 as the activity-dependent driver of oligodendrocyte glycolysis that ensures that lactate is supplied to active neurons. Given that oligodendrocyte Kir4.1 also influenced axonal glucose consumption and uptake, oligodendrocytes may play a broader role in neuronal metabolic regulation.
神经元具有较高的能量需求。在最近的一项研究中，Looser 等人发现少突胶质细胞 Kir4.1 是活性依赖性的少突胶质细胞糖酵解驱动因子，可确保将乳酸供应给活跃的神经元。鉴于少突胶质细胞 Kir4.1 还影响轴突葡萄糖的消耗和摄取，少突胶质细胞可能在神经元代谢调节中发挥更广泛的作用。
