Institute of Chemistry, University of Silesia in Katowice, Szkolna 9, 40-003 Katowice, Poland; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, H-1117 Budapest, Hungary; Faculty of Engineering, University of Pannonia, Egyetem u. 10, H-8200, Veszprém, Hungary.
Trends Mol Med. 2024 Aug;30(8):702-704. doi: 10.1016/j.molmed.2024.05.018. Epub 2024 Jun 11.
Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.
门德斯-戈麦斯等人最近展示了 RNA-脂质颗粒聚集体（RNA-LPAs）在免疫疗法中的变革潜力。通过重新编程肿瘤微环境（TME）和增强抗肿瘤免疫，RNA-LPAs 靶向原发性肿瘤并引发强烈的全身免疫。这一创新平台有望将临床前的成功转化为切实的临床获益。
