Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
Department of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing, 210029, China.
Theranostics. 2023 Mar 13;13(6):1774-1808. doi: 10.7150/thno.82920. eCollection 2023.
Metabolic reprogramming is one of the most important hallmarks of malignant tumors. Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and therapeutic response by remodeling the tumor microenvironment (TME). In the past few decades, immunotherapy has revolutionized the treatment landscape for advanced cancers. Lipid metabolic reprogramming plays pivotal role in regulating the immune microenvironment and response to cancer immunotherapy. Here, we systematically reviewed the characteristics, mechanism, and role of lipid metabolic reprogramming in tumor and immune cells in the TME, appraised the effects of various cell death modes (specifically ferroptosis) on lipid metabolism, and summarized the antitumor therapies targeting lipid metabolism. Overall, lipid metabolic reprogramming has profound effects on cancer immunotherapy by regulating the immune microenvironment; therefore, targeting lipid metabolic reprogramming may lead to the development of innovative clinical applications including sensitizing immunotherapy.
代谢重编程是恶性肿瘤的重要标志之一。具体而言，脂质代谢重编程通过重塑肿瘤微环境（TME），对癌症进展和治疗反应产生显著影响。在过去的几十年中，免疫疗法彻底改变了晚期癌症的治疗格局。脂质代谢重编程在调节免疫微环境和对癌症免疫疗法的反应中起着关键作用。在这里，我们系统地综述了脂质代谢重编程在 TME 中的肿瘤和免疫细胞中的特征、机制和作用，评估了各种细胞死亡模式（特别是铁死亡）对脂质代谢的影响，并总结了针对脂质代谢的抗肿瘤治疗方法。总的来说，脂质代谢重编程通过调节免疫微环境对癌症免疫疗法有深远影响；因此，靶向脂质代谢重编程可能会导致创新的临床应用的发展，包括增强免疫疗法。
