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探索以生物学为导向的精准心理健康举措用于饮食失调患者的护理:一项叙述性综述。

Exploring biologically oriented precision mental health initiatives for the care of patients with eating disorders: A narrative review.

作者信息

Norris Mark L

机构信息

Division of Adolescent Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.

出版信息

Eur Eat Disord Rev. 2024 Nov;32(6):1117-1137. doi: 10.1002/erv.3114. Epub 2024 Jun 12.

Abstract

OBJECTIVE

Eating disorders (EDs) represent a major public health burden. Increasingly, studies suggest mental health (MH) fields are failing to improve the effectiveness of treatments and that alternative models of care must be considered. Precision mental health (PMH) seeks to tailor treatment to individual needs and relies on a comprehensive understanding of the neurobiological and physiological underpinnings of mental illness.

METHODS

In this narrative review, published literature with focus on biological application of PMH strategies for EDs is reviewed and summarised.

RESULTS

A total of 39 articles were retained for the review covering a variety of themes with relevance to PMH. Many studies of biological markers with PMH applicability focused on anorexia nervosa. Although a variety of potential PMH research applications were identified, the review failed to identify any evidence of implementation into routine ED practice.

CONCLUSIONS

Despite the theoretical merit of biological application of PMH in ED treatment, clinical applications for standard practice are lacking. There is a need to invest further in studies that seek to identify biological markers and investigate neurobiological underpinnings of disease in hopes of targeting and developing treatments that can be better tailored to the individualised needs of patients.

摘要

目的

饮食失调是一项重大的公共卫生负担。越来越多的研究表明,心理健康领域未能提高治疗效果,必须考虑替代护理模式。精准心理健康旨在根据个体需求定制治疗方案,并依赖于对精神疾病的神经生物学和生理基础的全面理解。

方法

在这篇叙述性综述中,对聚焦于精准心理健康策略在饮食失调中的生物学应用的已发表文献进行了回顾和总结。

结果

总共保留了39篇文章用于综述,涵盖了与精准心理健康相关的各种主题。许多关于具有精准心理健康适用性的生物标志物的研究都集中在神经性厌食症上。尽管确定了各种潜在的精准心理健康研究应用,但综述未能找到任何将其应用于饮食失调常规治疗的证据。

结论

尽管精准心理健康在饮食失调治疗中的生物学应用具有理论价值,但缺乏标准实践中的临床应用。有必要进一步投资开展研究,以确定生物标志物并研究疾病的神经生物学基础,以期开发出能够更好地根据患者个体化需求定制的治疗方法。

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