Department of Rheumatology, Shanghai Pudong Hospital, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai 200000, China.
State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai 200000, China.
Chin Med J (Engl). 2024 Jul 20;137(14):1651-1662. doi: 10.1097/CM9.0000000000003169. Epub 2024 Jun 12.
Iron is indispensable for the viablility of nearly all living organisms, and it is imperative for cells, tissues, and organisms to acquire this essential metal sufficiently and maintain its metabolic stability for survival. Disruption of iron homeostasis can lead to the development of various diseases. There is a robust connection between iron metabolism and infection, immunity, inflammation, and aging, suggesting that disorders in iron metabolism may contribute to the pathogenesis of arthritis. Numerous studies have focused on the significant role of iron metabolism in the development of arthritis and its potential for targeted drug therapy. Targeting iron metabolism offers a promising approach for individualized treatment of arthritis. Therefore, this review aimed to investigate the mechanisms by which the body maintains iron metabolism and the impacts of iron and iron metabolism disorders on arthritis. Furthermore, this review aimed to identify potential therapeutic targets and active substances related to iron metabolism, which could provide promising research directions in this field.
铁是几乎所有生物体生存所必需的，细胞、组织和生物体必须充分获得这种必需的金属，并保持其代谢稳定性以维持生存。铁平衡的破坏可导致各种疾病的发生。铁代谢与感染、免疫、炎症和衰老之间存在着密切的联系，这表明铁代谢紊乱可能与关节炎的发病机制有关。许多研究都集中在铁代谢在关节炎发展中的重要作用及其作为靶向药物治疗的潜力。针对铁代谢进行治疗为关节炎的个体化治疗提供了一种很有前途的方法。因此，本综述旨在探讨机体维持铁代谢的机制，以及铁和铁代谢紊乱对关节炎的影响。此外，本综述旨在确定与铁代谢相关的潜在治疗靶点和活性物质，为该领域提供有前景的研究方向。
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