Effects of adjuvant arthritis on copper, zinc, and iron metabolism in the rat.

In a study on the effects of adjuvant arthritis on copper (Cu), zinc (Zn), and iron (Fe) metabolism in the rat, most significant changes were observed in the liver and pancreas where arthritis caused a large increase in the concentrations of all three metals. Results also indicated that although arthritis-induced changes in metal concentrations were highly correlated to inflammation and occurred in selected tissues only, these changes were not selective for copper.