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佐剂性关节炎对大鼠铜、锌和铁代谢的影响。

Effects of adjuvant arthritis on copper, zinc, and iron metabolism in the rat.

作者信息

Kishore V

机构信息

College of Pharmacy, Xavier University of Louisiana, New Orleans 70125.

出版信息

Res Commun Chem Pathol Pharmacol. 1989 Jan;63(1):153-6.

PMID:2916078
Abstract

In a study on the effects of adjuvant arthritis on copper (Cu), zinc (Zn), and iron (Fe) metabolism in the rat, most significant changes were observed in the liver and pancreas where arthritis caused a large increase in the concentrations of all three metals. Results also indicated that although arthritis-induced changes in metal concentrations were highly correlated to inflammation and occurred in selected tissues only, these changes were not selective for copper.

摘要

在一项关于佐剂性关节炎对大鼠铜（Cu）、锌（Zn）和铁（Fe）代谢影响的研究中，在肝脏和胰腺中观察到了最显著的变化，关节炎导致这三种金属的浓度大幅增加。结果还表明，虽然关节炎引起的金属浓度变化与炎症高度相关且仅在特定组织中发生，但这些变化并非铜所特有。

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2
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引用本文的文献

1
Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation.铜是促炎还是抗炎？一种调和的观点以及使用铜来控制炎症的新方法。
Agents Actions. 1993 Jul;39(3-4):210-7. doi: 10.1007/BF01998975.
2
Copper and zinc body levels in inflammation: an overview of the data obtained from animal and human studies.炎症状态下铜和锌的体内水平：来自动物和人体研究的数据综述
Agents Actions. 1993 Jul;39(3-4):195-209. doi: 10.1007/BF01998974.
3
Wasting in adjuvant-induced arthritis and its relationship to plasma zinc, copper and liver metallothionein.
佐剂性关节炎中的消瘦及其与血浆锌、铜和肝脏金属硫蛋白的关系。
Agents Actions. 1994 Aug;42(1-2):60-2. doi: 10.1007/BF02014302.
4
Trace element status and inflammation parameters during chronic indomethacin treatment in adjuvant arthritic rats.佐剂性关节炎大鼠慢性吲哚美辛治疗期间的微量元素状态和炎症参数
Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):209-18. doi: 10.1007/BF02790119.
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Effects of acute and chronic prednisolone treatment on serum zinc levels in rats with adjuvant arthritis.急性和慢性泼尼松龙治疗对佐剂性关节炎大鼠血清锌水平的影响。
Agents Actions. 1991 Jul;33(3-4):247-53. doi: 10.1007/BF01986570.
6
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Biol Trace Elem Res. 1990 May;25(2):123-35. doi: 10.1007/BF02990273.
7
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