Center for One Health, Global Center for Evidence Synthesis, Chandigarh, India.
Graphic Era (Deemed to be University), Clement Town, India.
QJM. 2024 Jul 1;117(7):485-487. doi: 10.1093/qjmed/hcae102.
The SARS-CoV-2 virus has undergone substantial evolution, leading to emergence of new FLiRT variants characterized by specific spike mutations-F to L at position 456 and R to T at position 346-enhancing their transmissibility and immune evasion capabilities. Particularly, KP.2 shows a significant increase in cases in the USA, indicating a potential shift in the pandemic landscape due to its greater ability to evade vaccine-induced immunity and its higher effective reproduction number compared to JN.1. This evolving scenario underscores the need for continuous monitoring and adaptive response strategies to address the challenges posed by these new variants. This abstract examines the emergence of FLiRT variants KP.2 and KP1.1, descendants of the Omicron JN.1 variant, as they draw global attention amidst the ongoing coronavirus disease-2019 pandemic.
SARS-CoV-2 病毒经历了大量进化，出现了新的 FLiRT 变体，其特征是刺突蛋白特定突变-F 到 L 位于位置 456 和 R 到 T 位于位置 346，增强了它们的传染性和免疫逃避能力。特别是，KP.2 在 美国的病例显著增加，表明由于其逃避疫苗诱导的免疫能力更强，以及与 JN.1 相比更高的有效繁殖数，大流行格局可能发生变化。这种不断演变的情况突显了需要持续监测和适应性应对策略来应对这些新变体带来的挑战。本文研究了 Omicron JN.1 变体的后代 FLiRT 变体 KP.2 和 KP1.1 的出现，因为它们在持续的 2019 冠状病毒病大流行中引起了全球关注。
