Ahmed Momitul, Kurungottu Pavithra, Swetha K, Atla Sandeep, Ashok Nivethitha, Nagamalleswari Easa, Bonam Srinivasa Reddy, Sahu Bidya Dhar, Kurapati Rajendra
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, India.
School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram 695551, India.
Biomater Sci. 2025 Apr 29;13(9):2164-2178. doi: 10.1039/d4bm00439f.
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is pivotal in orchestrating the immune response induced by nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of NLRP3 inflammasome by these adjuvants is crucial for deciphering their immunomodulatory properties. This review explores the involvement of the NLRP3 inflammasome in mediating immune responses triggered by nanoparticle adjuvants. It delves into the signaling pathways and cellular mechanisms involved in NLRP3 activation, highlighting its significance in modulating the efficacy and safety of nanoparticle-based adjuvants. A comprehensive grasp of the interplay between NLRP3 inflammasome and nanoparticle adjuvants holds promise for optimizing vaccine design and advancing immunotherapeutic strategies.
核苷酸结合寡聚化结构域（NOD）样受体（NLR）家族含吡啉结构域3（NLRP3）炎性小体在协调纳米颗粒佐剂诱导的免疫反应中起关键作用。了解这些佐剂激活NLRP3炎性小体的复杂机制对于解读其免疫调节特性至关重要。本综述探讨了NLRP3炎性小体在介导纳米颗粒佐剂引发的免疫反应中的作用。它深入研究了NLRP3激活所涉及的信号通路和细胞机制，强调了其在调节基于纳米颗粒的佐剂的功效和安全性方面的重要性。全面掌握NLRP3炎性小体与纳米颗粒佐剂之间的相互作用有望优化疫苗设计并推进免疫治疗策略。
