法属圭亚那镰状细胞病患者感染新型冠状病毒肺炎的临床结局

Clinical outcomes of COVID-19 in patients with sickle cell disease in French Guiana.

作者信息

Elenga Narcisse, Ntab Baltazar, Mafema Missindu Joddy, Thomas Boizan Noelis, Abassi Alio

机构信息

Service de Pédiatrie, Centre Hospitalier de Cayenne, Rue des Flamboyants, BP 6006, 97306 Cayenne, Cedex, Guiana, France.

Centre de Reference de La Drépanocytose, Centre Hospitalier de Cayenne, Rue des Flamboyants, BP 6006, 97306, Cayenne, Cedex, Guiana, France.

出版信息

Heliyon. 2024 May 31;10(11):e32017. doi: 10.1016/j.heliyon.2024.e32017. eCollection 2024 Jun 15.

DOI:10.1016/j.heliyon.2024.e32017

PMID:38868053

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11168310/

Abstract

OBJECTIVES

French Guiana also suffered concrete epidemiological consequences of the SARS-CoV2 epidemic. These regions are home to a large number of sickle cell patients who are at risk of developing severe forms of COVID-19. This study aimed to describe the characteristics and prognosis of patients with sickle disease infected with SARS-CoV2 during the first and second epidemic waves of 2020 in French Guiana.

DESIGN

We conducted a multicenter, retrospective cohort study that included sickle cell patients followed up in French Guiana.

RESULTS

Among the 79 patients infected with SARS-CoV2, there were 26 children <18 years. Forty-two patients were hospitalized and 37 were outpatients. Respiratory illness (38 %), vaso-occlusive crises (18 %), and acute chest syndrome (8 %) were the main causes of hospitalization. There were two cases of pulmonary embolism and one case of deep limb thrombosis. Seven patients were transferred to the ICU. Of these, three received mechanical ventilation, and two died. The deceased patients had the SS phenotype (a 16-year-old boy and a 32-year-old man), both of whom exhibited severe pneumonitis complicated by COVID-19.

CONCLUSION

Despite the two deaths, the overall outcome was favorable.

摘要

目的

法属圭亚那也遭受了新冠病毒疫情的具体流行病学后果。这些地区有大量镰状细胞病患者，他们有发展为重症新冠肺炎的风险。本研究旨在描述2020年法属圭亚那第一波和第二波疫情期间感染新冠病毒的镰状细胞病患者的特征和预后。

设计

我们开展了一项多中心回顾性队列研究，纳入了在法属圭亚那接受随访的镰状细胞病患者。

结果

在79例感染新冠病毒的患者中，有26名儿童年龄小于18岁。42例患者住院，37例为门诊患者。呼吸系统疾病（38%）、血管闭塞性危机（18%）和急性胸综合征（8%）是住院的主要原因。有2例肺栓塞和1例下肢深静脉血栓形成。7例患者被转入重症监护病房。其中，3例接受了机械通气，2例死亡。死亡患者具有SS基因型（一名16岁男孩和一名32岁男性），两人均表现为严重肺炎并伴有新冠肺炎。