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肉瘤细胞矿工数据库：一种用于探究肉瘤细胞系综合集合的基因组和功能特征的工具。

Sarcoma_CellminerCDB: A tool to interrogate the genomic and functional characteristics of a comprehensive collection of sarcoma cell lines.

作者信息

Tlemsani Camille, Heske Christine M, Elloumi Fathi, Pongor Lorinc, Khandagale Prashant, Varma Sudhir, Luna Augustin, Meltzer Paul S, Khan Javed, Reinhold William C, Pommier Yves

机构信息

Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM, Université Paris Cité, APHP. Centre, Paris, France.

出版信息

iScience. 2024 Apr 18;27(6):109781. doi: 10.1016/j.isci.2024.109781. eCollection 2024 Jun 21.

DOI:10.1016/j.isci.2024.109781
PMID:38868205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11167437/
Abstract

Sarcomas are a diverse group of rare malignancies composed of multiple different clinical and molecular subtypes. Due to their rarity and heterogeneity, basic, translational, and clinical research in sarcoma has trailed behind that of other cancers. Outcomes for patients remain generally poor due to an incomplete understanding of disease biology and a lack of novel therapies. To address some of the limitations impeding preclinical sarcoma research, we have developed Sarcoma_CellMinerCDB, a publicly available interactive tool that merges publicly available sarcoma cell line data and newly generated omics data to create a comprehensive database of genomic, transcriptomic, methylomic, proteomic, metabolic, and pharmacologic data on 133 annotated sarcoma cell lines. The reproducibility, functionality, biological relevance, and therapeutic applications of Sarcoma_CellMinerCDB described herein are powerful tools to address and generate biological questions and test hypotheses for translational research. Sarcoma_CellMinerCDB (https://discover.nci.nih.gov/SarcomaCellMinerCDB) aims to contribute to advancing the preclinical study of sarcoma.

摘要

肉瘤是一组由多种不同临床和分子亚型组成的罕见恶性肿瘤。由于其罕见性和异质性，肉瘤的基础、转化和临床研究落后于其他癌症。由于对疾病生物学的理解不完整以及缺乏新的治疗方法，患者的预后总体仍然很差。为了解决一些阻碍临床前肉瘤研究的局限性，我们开发了Sarcoma_CellMinerCDB，这是一个公开可用的交互式工具，它将公开可用的肉瘤细胞系数据和新生成的组学数据合并，以创建一个关于133个注释肉瘤细胞系的基因组、转录组、甲基化组、蛋白质组、代谢组和药理学数据的综合数据库。本文所述的Sarcoma_CellMinerCDB的可重复性、功能、生物学相关性和治疗应用是解决和产生生物学问题以及检验转化研究假设的有力工具。Sarcoma_CellMinerCDB（https://discover.nci.nih.gov/SarcomaCellMinerCDB）旨在促进肉瘤的临床前研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/e988c6773304/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/cf15f71cb001/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/4f3958a282a9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/c457dad88097/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/6b376a590a9c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/4e3ea8f222ab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/b12b76d8c900/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/e988c6773304/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/cf15f71cb001/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/4f3958a282a9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/c457dad88097/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/6b376a590a9c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/4e3ea8f222ab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/b12b76d8c900/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac2/11167437/e988c6773304/gr6.jpg

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Cancer Res. 2025 Jan 2;85(1):154-170. doi: 10.1158/0008-5472.CAN-23-3603.
吉妥珠单抗-奥唑米星在急性髓系白血病治疗中作用的最新进展
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