• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

IRX5对甲状腺乳头状癌中巨噬细胞极化及预后的影响。

IRX5's influence on macrophage polarization and outcome in papillary thyroid cancer.

作者信息

Qin Lu, Chen Cheng, Gui Zhengwei, Jiang Yun

机构信息

Department of Thyroid Vascular Surgery, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, ;China.

Department of Nuclear Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, ;China.

出版信息

Front Oncol. 2024 May 29;14:1399484. doi: 10.3389/fonc.2024.1399484. eCollection 2024.

DOI:10.3389/fonc.2024.1399484
PMID:38868535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11167072/
Abstract

BACKGROUND

With a rise in recent years, thyroid cancer (TC) is the most prevalent hormonal cancer worldwide. It is essential to investigate the inherent variability at the molecular level and the immune environment within tumors of various thyroid cancer subtypes in order to identify potential targets for therapy and provide precise treatment for patients with thyroid adenocarcinoma.

METHODS

First, we analyzed the expression of IRX5 in pan-cancer and papillary thyroid carcinoma by bioinformatics methods and collected paired samples from our center for validation. Subsequently, we analyzed the significance of IRX5 on the prognosis and diagnosis of PTC. Next, we explored the possible mechanisms by which IRX5 affects the prognosis of thyroid cancer patients by GO/KEGG enrichment analysis, and further investigated the effect of IRX5 on immune infiltration of thyroid cancer. Ultimately, by conducting experiments on cells and animals, we were able to show how IRX5 impacts the aggressive characteristics of thyroid cancer cells and its influence on macrophages within the immune system of thyroid cancer.

RESULTS

In 11 malignant tumors, including PTC, IRX5 is overexpressed and associated with a poor prognosis. IRX5 may affect the prognosis of PTC through embryonic organ development, ossification, mesenchyme development, etc. Increased IRX5 expression decreases the presence of cytotoxic and Th17 cells in papillary thyroid cancer. IRX5 was highly expressed in different PTC cell lines, such as K-1 and TPC-1. Silencing IRX5 effectively halted the growth and movement of PTC cells while also decreasing M2 polarization and enhancing M1 polarization in tumor-associated macrophages.

CONCLUSION

IRX5 could impact the outlook of individuals with PTC by stimulating the shift of macrophages to M2 in the immune surroundings of thyroid cancer growths, suggesting a potential new focus for treating thyroid cancer, particularly through immunotherapy.

摘要

背景

近年来，甲状腺癌（TC）的发病率呈上升趋势，是全球最常见的激素相关癌症。为了确定潜在的治疗靶点并为甲状腺腺癌患者提供精准治疗，研究不同甲状腺癌亚型肿瘤在分子水平的内在变异性和免疫环境至关重要。

方法

首先，我们通过生物信息学方法分析了IRX5在泛癌和甲状腺乳头状癌中的表达情况，并收集了我们中心的配对样本进行验证。随后，我们分析了IRX5对甲状腺乳头状癌预后和诊断的意义。接下来，我们通过基因本体论（GO）/京都基因与基因组百科全书（KEGG）富集分析探索了IRX5影响甲状腺癌患者预后的可能机制，并进一步研究了IRX5对甲状腺癌免疫浸润的影响。最终，通过细胞和动物实验，我们展示了IRX5如何影响甲状腺癌细胞的侵袭特性及其对甲状腺癌免疫系统中巨噬细胞的影响。

结果

在包括甲状腺乳头状癌在内的11种恶性肿瘤中，IRX5表达上调且与不良预后相关。IRX5可能通过胚胎器官发育、骨化、间充质发育等影响甲状腺乳头状癌的预后。IRX5表达增加会降低甲状腺乳头状癌中细胞毒性细胞和Th17细胞的数量。IRX5在不同的甲状腺乳头状癌细胞系，如K-1和TPC-1中高表达。沉默IRX5可有效抑制甲状腺乳头状癌细胞的生长和迁移，同时减少肿瘤相关巨噬细胞的M2极化并增强M1极化。

结论

IRX5可能通过促进甲状腺癌生长免疫环境中巨噬细胞向M2型转变，影响甲状腺乳头状癌患者的预后，这为甲状腺癌治疗，尤其是免疫治疗提供了一个潜在的新靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/084ff6d1b923/fonc-14-1399484-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/932bd25c8ff9/fonc-14-1399484-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/dfbeaef9ae49/fonc-14-1399484-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/3cf3ca85e4de/fonc-14-1399484-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/cf80cb12859e/fonc-14-1399484-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/7c0761c3731c/fonc-14-1399484-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/f04bf10f583e/fonc-14-1399484-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/26f30fe0415b/fonc-14-1399484-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/d4ae05285dcd/fonc-14-1399484-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/084ff6d1b923/fonc-14-1399484-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/932bd25c8ff9/fonc-14-1399484-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/dfbeaef9ae49/fonc-14-1399484-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/3cf3ca85e4de/fonc-14-1399484-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/cf80cb12859e/fonc-14-1399484-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/7c0761c3731c/fonc-14-1399484-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/f04bf10f583e/fonc-14-1399484-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/26f30fe0415b/fonc-14-1399484-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/d4ae05285dcd/fonc-14-1399484-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f67e/11167072/084ff6d1b923/fonc-14-1399484-g009.jpg

相似文献

1
IRX5's influence on macrophage polarization and outcome in papillary thyroid cancer.IRX5对甲状腺乳头状癌中巨噬细胞极化及预后的影响。
Front Oncol. 2024 May 29;14:1399484. doi: 10.3389/fonc.2024.1399484. eCollection 2024.
2
Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment.甲状腺乳头状癌微环境中的免疫细胞对抗。
Front Endocrinol (Lausanne). 2020 Oct 22;11:570604. doi: 10.3389/fendo.2020.570604. eCollection 2020.
3
Identification of ferroptosis genes in immune infiltration and prognosis in thyroid papillary carcinoma using network analysis.利用网络分析鉴定甲状腺乳头状癌免疫浸润和预后中的铁死亡基因
BMC Genomics. 2021 Jul 27;22(1):576. doi: 10.1186/s12864-021-07895-6.
4
Bleomycin inhibits proliferation and induces apoptosis in TPC-1 cells through reversing M2-macrophages polarization.博来霉素通过逆转M2巨噬细胞极化抑制TPC-1细胞增殖并诱导其凋亡。
Oncol Lett. 2018 Sep;16(3):3858-3866. doi: 10.3892/ol.2018.9103. Epub 2018 Jul 6.
5
Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.LPAR5 基因在甲状腺乳头状癌及泛癌预后和免疫中的潜在作用
Sci Rep. 2023 Apr 10;13(1):5850. doi: 10.1038/s41598-023-32733-y.
6
Network Pharmacological Analysis and Experimental Validation of the Effects of Silybin on Proliferation, Migration, and Immunotherapy of Papillary Thyroid Cancer.基于网络药理学分析和实验验证水飞蓟宾对甲状腺乳头状癌细胞增殖、迁移和免疫治疗的作用
Endocr Metab Immune Disord Drug Targets. 2024;24(6):672-690. doi: 10.2174/0118715303248000230922185110.
7
Tumor-Infiltrating Immune Cell Landscapes in the Lymph Node Metastasis of Papillary Thyroid Cancer.甲状腺乳头状癌淋巴结转移中的肿瘤浸润免疫细胞图谱。
Curr Oncol. 2023 Feb 22;30(3):2625-2641. doi: 10.3390/curroncol30030200.
8
MiR-374a/b-5p Suppresses Cell Growth in Papillary Thyroid Carcinoma Through Blocking Exosomal ANXA1-Induced Macrophage M2 Polarization.微小RNA-374a/b-5p通过阻断外泌体膜联蛋白A1诱导的巨噬细胞M2极化抑制甲状腺乳头状癌的细胞生长。
Biochem Genet. 2025 Apr;63(2):1258-1274. doi: 10.1007/s10528-024-10747-z. Epub 2024 Mar 27.
9
Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment.桥本病对甲状腺乳头状癌进展影响的作用机制：与肿瘤免疫微环境的关系。
Endocrinol Metab (Seoul). 2020 Jun;35(2):443-455. doi: 10.3803/EnM.2020.35.2.443. Epub 2020 Jun 24.
10
STRA6 regulates tumor immune microenvironment and is a prognostic marker in BRAF-mutant papillary thyroid carcinoma.STRA6 调节肿瘤免疫微环境，是 BRAF 突变型甲状腺乳头状癌的预后标志物。
Front Endocrinol (Lausanne). 2023 Feb 10;14:1076640. doi: 10.3389/fendo.2023.1076640. eCollection 2023.

引用本文的文献

1
Thyroid Cancer-The Tumor Immune Microenvironment (TIME) over Time and Space.甲状腺癌——肿瘤免疫微环境（TIME）的时空变化
Cancers (Basel). 2025 Feb 26;17(5):794. doi: 10.3390/cancers17050794.
2
The Application of microRNAs in Papillary Thyroid Cancer: A Bibliometric and Visualized Analysis.微小RNA在甲状腺乳头状癌中的应用：文献计量学与可视化分析
Int J Gen Med. 2024 Oct 15;17:4681-4699. doi: 10.2147/IJGM.S487239. eCollection 2024.

本文引用的文献

1
Global scientific trends on thyroid disease in early 21st century: a bibliometric and visualized analysis.21 世纪初甲状腺疾病的全球科学趋势：文献计量学和可视化分析。
Front Endocrinol (Lausanne). 2024 Jan 17;14:1306232. doi: 10.3389/fendo.2023.1306232. eCollection 2023.
2
IRX5 promotes DNA damage repair and activation of hair follicle stem cells.IRX5 促进 DNA 损伤修复和毛囊干细胞激活。
Stem Cell Reports. 2023 May 9;18(5):1227-1243. doi: 10.1016/j.stemcr.2023.03.013. Epub 2023 Apr 20.
3
Risk and Prognostic Factors for BRAF Mutations in Papillary Thyroid Carcinoma.
甲状腺乳头状癌中 BRAF 突变的风险和预后因素。
Biomed Res Int. 2022 May 18;2022:9959649. doi: 10.1155/2022/9959649. eCollection 2022.
4
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
5
Senescent thyroid tumor cells promote their migration by inducing the polarization of M2-like macrophages.衰老的甲状腺肿瘤细胞通过诱导 M2 样巨噬细胞极化来促进其迁移。
Clin Transl Oncol. 2021 Jun;23(6):1253-1261. doi: 10.1007/s12094-020-02516-2. Epub 2021 Jan 3.
6
Tumor-Associated Macrophages in Tumor Immunity.肿瘤相关巨噬细胞在肿瘤免疫中的作用。
Front Immunol. 2020 Dec 3;11:583084. doi: 10.3389/fimmu.2020.583084. eCollection 2020.
7
M2-like tumor-associated macrophages-secreted Wnt1 and Wnt3a promotes dedifferentiation and metastasis via activating β-catenin pathway in thyroid cancer.M2 样肿瘤相关巨噬细胞分泌的 Wnt1 和 Wnt3a 通过激活甲状腺癌细胞中的β-catenin 通路促进去分化和转移。
Mol Carcinog. 2021 Jan;60(1):25-37. doi: 10.1002/mc.23268. Epub 2020 Dec 7.
8
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.ILC2 驱动的固有免疫检查点机制拮抗 NK 细胞在肺部的抗转移功能。
Nat Immunol. 2020 Sep;21(9):998-1009. doi: 10.1038/s41590-020-0745-y. Epub 2020 Aug 3.
9
SnapShot: TP53 status and macrophages infiltration in TCGA-analyzed tumors.快照：TCGA 分析肿瘤中的 TP53 状态和巨噬细胞浸润。
Int Immunopharmacol. 2020 Sep;86:106758. doi: 10.1016/j.intimp.2020.106758. Epub 2020 Jul 11.
10
IRX5 prompts genomic instability in colorectal cancer cells.IRX5 导致结直肠癌细胞基因组不稳定。
J Cell Biochem. 2020 Nov;121(11):4680-4689. doi: 10.1002/jcb.29693. Epub 2020 Mar 11.