胍法辛治疗老年患者的易怒、冲动和激动：两例报告。
Guanfacine for irritability, impulsivity, and agitation in elderly patients: A report of two cases.
作者信息
Miyoshi Takafumi, Noborio Yayoi, Hoonhwa Chang, Ishimori Yuki
机构信息
Department of Psychiatry Itami City Hospital, Itami-shi Hyogo Japan.
Department of Nursing Itami City Hospital, Itami-shi Hyogo Japan.
出版信息
PCN Rep. 2022 May 18;1(2):e14. doi: 10.1002/pcn5.14. eCollection 2022 Jun.
BACKGROUND
Irritability, impulsivity, and agitation in elderly patients with dementia are highly prevalent and extremely burdening for patients, caregivers, and medical staff. In general hospitals, they have been one of the major problems that develop and disturb care and treatment. However, the mechanisms underlying these symptoms remain unclear, and there is no established treatment. In actual clinical practice, antipsychotic drugs and mood stabilizers have been mainly used as pharmacotherapies for these symptoms, but adverse effects of these drugs have often been problematic.
CASE PRESENTATION
We report two valuable cases of elderly patients who were admitted to our hospital due to physical disorders and developed irritability, impulsivity, and agitation, which were effectively treated with guanfacine at very low doses and in a short period.
CONCLUSION
The present cases suggest that guanfacine may be a therapeutic option for treating irritability, impulsivity, and agitation in elderly patients.
背景
老年痴呆患者的易激惹、冲动和激越现象非常普遍，给患者、照料者和医护人员带来极大负担。在综合医院，这些现象一直是影响和干扰护理及治疗的主要问题之一。然而，这些症状背后的机制仍不清楚，且尚无既定的治疗方法。在实际临床实践中，抗精神病药物和心境稳定剂一直是治疗这些症状的主要药物疗法，但这些药物的不良反应常常成为问题。
病例报告
我们报告两例有价值的老年患者病例，他们因躯体疾病入院，出现了易激惹、冲动和激越症状，通过极低剂量且短期使用胍法辛得到了有效治疗。
结论
目前的病例表明，胍法辛可能是治疗老年患者易激惹、冲动和激越的一种治疗选择。
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