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本文引用的文献

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2
Thrombotic antiphospholipid syndrome in a child with human immunodeficiency virus: a rare case report.一名感染人类免疫缺陷病毒儿童的血栓性抗磷脂综合征：一例罕见病例报告。
Thromb J. 2021 Mar 25;19(1):20. doi: 10.1186/s12959-021-00273-y.
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Management of anticoagulation in patients with human immunodeficiency virus/acquired immunodeficiency virus.艾滋病毒/获得性免疫缺陷病毒患者的抗凝管理。
Thromb Res. 2021 Apr;200:102-108. doi: 10.1016/j.thromres.2021.01.020. Epub 2021 Jan 27.
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Comparison of pathological clotting using haematological, functional and morphological investigations in HIV-positive and HIV-negative patients with deep vein thrombosis.比较 HIV 阳性和 HIV 阴性深静脉血栓形成患者的血液学、功能和形态学检查中的病理性血栓形成。
Retrovirology. 2020 Jun 22;17(1):14. doi: 10.1186/s12977-020-00523-3.
5
Utilization of Direct Oral Anticoagulants in People Living with Human Immunodeficiency Virus: Observational Data from the District of Columbia Cohort.直接口服抗凝剂在人类免疫缺陷病毒感染者中的应用：来自哥伦比亚特区队列的观察性数据。
Clin Infect Dis. 2020 Dec 17;71(10):e604-e613. doi: 10.1093/cid/ciaa284.
6
Direct oral anticoagulants for the management of venous thromboembolism in patients with HIV - a single centre experience.直接口服抗凝剂用于治疗HIV患者的静脉血栓栓塞——单中心经验
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7
Deep-vein thrombosis in the era of high HIV and tuberculosis prevalence: A prospective review of its diagnosis and treatment in a quaternary centre.艾滋病病毒和结核病高流行时代的深静脉血栓形成：一家四级医疗中心对其诊断和治疗的前瞻性综述
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8
A Case Series of HIV-Seropositive Patients and Hypercoagulable State-Is It Difficult to Treat Even with Therapeutic Anticoagulation?一组HIV血清阳性患者与高凝状态病例系列——即使采用治疗性抗凝治疗也难以治疗吗？
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一名接受抗凝治疗的HIV感染患者发生深静脉血栓形成的病例。

A Case of Deep Venous Thrombosis in an HIV-Infected Patient despite Therapeutic Anticoagulation.

作者信息

Aiman Wajeeha, Ali Muhammad Ashar, Grewal Navjot, Bethel Nyan, Savopoulos Andreas A, Guron Gunwant

机构信息

Saint Michael's Medical Center, New York College of Medicine, Newark, NJ, USA.

Saint Clare's and St. Mary's General Hospital, Denville, NJ, USA.

出版信息

Int J Hematol Oncol Stem Cell Res. 2024 Apr 1;18(2):206-209. doi: 10.18502/ijhoscr.v18i2.15379.

DOI:10.18502/ijhoscr.v18i2.15379
PMID:38868809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11166488/
Abstract

Patients with human immunodeficiency virus (HIV) infection have an increased likelihood of venous thromboembolism (VTE) owing to factors such as acquired protein C and S deficiency, antiphospholipid antibody syndrome, and heightened levels of pro-inflammatory cytokines. This case report highlights an exceptionally uncommon occurrence of deep venous thrombosis in an HIV-infected patient receiving a therapeutic dose of enoxaparin. This underscores the need for cautious consideration of the risk of VTE in HIV-infected individuals, even with preventive or therapeutic anticoagulant treatment. Further research is recommended to investigate HIV as a potential risk factor of prophylactic anticoagulation.

摘要

由于获得性蛋白C和S缺乏、抗磷脂抗体综合征以及促炎细胞因子水平升高，人类免疫缺陷病毒（HIV）感染患者发生静脉血栓栓塞（VTE）的可能性增加。本病例报告强调了在接受治疗剂量依诺肝素的HIV感染患者中发生深静脉血栓形成这一极为罕见的情况。这突出了即使在进行预防性或治疗性抗凝治疗时，也需要谨慎考虑HIV感染个体发生VTE的风险。建议进一步开展研究，以调查HIV作为预防性抗凝潜在风险因素的情况。