Wang Sabrina D, Wroblewski Kristen E, Iveniuk James, Schumm L Phillip, Hawkley Louise C, McClintock Martha K, Huang Elbert S
Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.
Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.
J Racial Ethn Health Disparities. 2025 Aug;12(4):2261-2269. doi: 10.1007/s40615-024-02046-5. Epub 2024 Jun 13.
Racial and ethnic minorities are disproportionately affected by diabetes. Social characteristics, such as family structure, social support, and loneliness, may contribute to these health disparities. In a nationally representative sample of diverse older adults, we evaluated longitudinal rates of both progression from prediabetes to diabetes and reversion from prediabetes to normoglycemia.
Using the longitudinal Health and Retirement Study (2006-2014), our sample included 2625 follow-up intervals with a prediabetes baseline (provided by 2229 individuals). We analyzed 4-year progression and reversion rates using HbA1c and reported presence or absence of physician-diagnosed diabetes. We utilized chi-square and logistic regression models to determine how race/ethnicity and social variables influenced progression or reversion controlling for comorbidities and demographics.
Overall, progression to diabetes was less common than reversion (17% vs. 36%). Compared to Whites, Hispanic/Latino respondents had higher odds of progression to diabetes from prediabetes while Black respondents had lower odds of reversion, adjusting for physical health and demographics. For social variables, Hispanics/Latinos had the highest reliance on and openness with family and the lowest rates of loneliness. The inclusion of social variables in regression models reduced the odds of progression for Hispanics/Latinos but did not alter Black's lower rate of reversion.
Hispanic/Latinos and Blacks not only had different transition pathways leading to diabetes, but also had different social profiles, affecting Hispanic/Latino progression, but not Black reversion. These differences in the influence of social variables on diabetes risk may inform the design of culturally-specific efforts to reduce disparities in diabetes burden.
糖尿病对种族和少数族裔的影响尤为严重。家庭结构、社会支持和孤独感等社会特征可能导致这些健康差异。在一个具有全国代表性的不同老年人群样本中,我们评估了糖尿病前期进展为糖尿病以及糖尿病前期逆转至血糖正常的纵向发生率。
利用纵向的健康与退休研究(2006 - 2014年),我们的样本包括2625个以糖尿病前期为基线的随访间隔(由2229名个体提供)。我们使用糖化血红蛋白分析了4年的进展和逆转率,并报告了是否存在医生诊断的糖尿病。我们利用卡方检验和逻辑回归模型来确定种族/族裔和社会变量如何在控制合并症和人口统计学因素的情况下影响进展或逆转。
总体而言,进展为糖尿病的情况比逆转更为少见(17%对36%)。与白人相比,西班牙裔/拉丁裔受访者从糖尿病前期进展为糖尿病的几率更高,而黑人受访者逆转的几率更低,这是在对身体健康和人口统计学因素进行调整之后得出的。对于社会变量,西班牙裔/拉丁裔对家庭的依赖程度和开放程度最高,孤独感发生率最低。在回归模型中纳入社会变量降低了西班牙裔/拉丁裔进展的几率,但并未改变黑人较低的逆转率。
西班牙裔/拉丁裔和黑人不仅通向糖尿病的转变途径不同,而且社会概况也不同,社会概况影响西班牙裔/拉丁裔的进展,但不影响黑人的逆转。社会变量对糖尿病风险影响的这些差异可能为设计针对特定文化的努力以减少糖尿病负担差异提供参考。