Collatuzzo Giulia, Rashidian Hamideh, Hadji Maryam, Naghibzadeh Ahmad, Alizadeh-Navaei Reza, Boffetta Paolo, Zendehdel Kazem
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Eur J Cancer Prev. 2025 Mar 1;34(2):151-156. doi: 10.1097/CEJ.0000000000000902. Epub 2024 Jun 14.
We aimed to investigate the association between cigarettes and waterpipe use and colorectal cancer (CRC) in an Iranian population. We analyzed data from a multicenter hospital-based case-control study in Iran (IROPICAN). Data on tobacco smoking, including cigarettes, and waterpipe smoking, were collected in detail. Multivariate logistic regressions estimated the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between cigarette and waterpipe smoking and CRC, accounting for confounders including age, sex, socioeconomic status, opium use, marital status, family history of cancer, red meat, fiber, body shape at age 15 and perceived physical workload, and each other of the two exposures. The study population consisted of 3215 controls and 848 cases, including 455 colon and 393 rectum cancers. We found no association between CRC and cigarette smoking (OR, 0.8; 95% CI, 0.6-1.0) or waterpipe smoking (OR, 1.1; 95% CI, 0.9-1.5). Analysis by categories of cigarette pack-year and frequency of waterpipe smoking (head-year) did not show associations. We observed an inverse association between colon cancer and cigarette smoking (OR, 0.6; 95% CI, 0.5-0.9). There was, however, no significant association by pack-year categories. Cigarette and waterpipe smoking was not associated with CRC in the Iranian population. Further studies are needed to better understand the role of waterpipe on CRC.
我们旨在调查伊朗人群中香烟和水烟使用与结直肠癌（CRC）之间的关联。我们分析了来自伊朗一项基于医院的多中心病例对照研究（IROPICAN）的数据。详细收集了包括香烟在内的烟草吸烟和水烟吸烟的数据。多变量逻辑回归估计了香烟和水烟吸烟与CRC之间关联的比值比（OR）和95%置信区间（CI），同时考虑了年龄、性别、社会经济地位、鸦片使用、婚姻状况、癌症家族史、红肉、纤维、15岁时的体型和感知到的体力工作量等混杂因素，以及两种暴露因素之间的相互影响。研究人群包括3215名对照和848例病例，其中包括455例结肠癌和393例直肠癌。我们发现CRC与吸烟（OR，0.8；95%CI，0.6 - 1.0）或水烟吸烟（OR，1.1；95%CI，0.9 - 1.5）之间无关联。按香烟包年数和水烟吸烟频率（首年）分类进行分析未显示出关联。我们观察到结肠癌与吸烟之间存在负相关（OR，0.6；95%CI，0.5 - 0.9）。然而，按包年数分类并无显著关联。在伊朗人群中，香烟和水烟吸烟与CRC无关。需要进一步研究以更好地了解水烟对CRC的作用。
