Wu Yuxiang, Ma Weiwei, Cheng Zhenda, Zhang Qiwei, Li Zhaodong, Weng Punan, Li Bushuang, Huang Zhiqiang, Fu Changlong
Quanzhou Hospital of Traditional Chinese Medicine, Quanzhou, Fujian, China.
Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
PLoS One. 2024 Jun 13;19(6):e0298610. doi: 10.1371/journal.pone.0298610. eCollection 2024.
Utilizing the Mendelian randomization technique, this research clarifies the putative causal relationship between body mass index (BMI) andbone mineral density (BMD), and the mediating role of low-density lipoprotein (LDL). The implications of these findings present promising opportunities for enhancing our understanding of complex bone-related characteristics and disorders, offering potential directions for treatment and intervention.
The objective of this study is to examine the correlation between BMI and BMD, while exploring the intermediary role of LDL in mediating the causal impact of BMI on BMD outcomes via Mendelian randomization.
In this study, we employed genome-wide association study (GWAS) data on BMI, LDL, and BMD to conduct a comparative analysis using both univariate and multivariate Mendelian randomization.
Our study employed a two-sample Mendelian randomization design. Considering BMI as the exposure and BMD as the outcome, our results suggest that BMI may function as a potential protective factor for BMD (β = 0.05, 95% CI 1.01 to 1.09, P = 0.01). However, when treating LDL as the exposure and BMD as the outcome, our findings indicate LDL as a risk factor for BMD (β = -0.04, 95% CI 0.92 to 0.99, P = 0.04). In our multivariate Mendelian randomization (MVMR) model, the combined influence of BMI and LDL was used as the exposure for BMD outcomes. The analysis pointed towards a substantial protective effect of LDL on BMD (β = 0.08, 95% CI 0.85 to 0.97, P = 0.006). In the analysis of mediation effects, LDL was found to mediate the relationship between BMI and BMD, and the effect was calculated at (β = 0.05, 95% CI 1.052 to 1.048, P = 0.04).
Our findings suggest that BMI may be considered a protective factor for BMD, while LDL may act as a risk factor. Moreover, LDL appears to play a mediatory role in the causal influence of BMI on BMD.
本研究运用孟德尔随机化技术，阐明了体重指数（BMI）与骨密度（BMD）之间的假定因果关系，以及低密度脂蛋白（LDL）的中介作用。这些发现为增进我们对复杂的骨相关特征和疾病的理解提供了有前景的机会，为治疗和干预提供了潜在方向。
本研究的目的是检验BMI与BMD之间的相关性，同时通过孟德尔随机化探索LDL在介导BMI对BMD结果的因果影响中的中介作用。
在本研究中，我们使用了关于BMI、LDL和BMD的全基因组关联研究（GWAS）数据，采用单变量和多变量孟德尔随机化进行比较分析。
我们的研究采用了两样本孟德尔随机化设计。将BMI作为暴露因素，BMD作为结果，我们的结果表明BMI可能是BMD的潜在保护因素（β = 0.05，95%可信区间1.01至1.09，P = 0.01）。然而，当将LDL作为暴露因素，BMD作为结果时，我们的发现表明LDL是BMD的危险因素（β = -0.04，95%可信区间0.92至0.99，P = 0.04）。在我们的多变量孟德尔随机化（MVMR）模型中，将BMI和LDL的联合影响作为BMD结果的暴露因素。分析表明LDL对BMD有显著的保护作用（β = 0.08，95%可信区间0.85至0.97，P = 0.006）。在中介效应分析中，发现LDL介导了BMI与BMD之间的关系，效应计算为（β = 0.05，95%可信区间1.052至1.048，P = 0.04）。
我们的研究结果表明，BMI可能被视为BMD的保护因素，而LDL可能是危险因素。此外，LDL似乎在BMI对BMD的因果影响中起中介作用。
