Interfaculty Institute for Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany; M3-Research Center for Malignome, Metabolome and Microbiome, University of Tübingen, Tübingen, Germany.
Interfaculty Institute for Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany; M3-Research Center for Malignome, Metabolome and Microbiome, University of Tübingen, Tübingen, Germany.
Cell Host Microbe. 2024 Jun 12;32(6):786-793. doi: 10.1016/j.chom.2024.05.009.
Survival strategies of human-associated microbes to drug exposure have been mainly studied in the context of bona fide pathogens exposed to antibiotics. Less well understood are the survival strategies of non-pathogenic microbes and host-associated commensal communities to the variety of drugs and xenobiotics to which humans are exposed. The lifestyle of microbial commensals within complex communities offers a variety of ways to adapt to different drug-induced stresses. Here, we review the responses and survival strategies employed by gut commensals when exposed to drugs-antibiotics and non-antibiotics-at the individual and community level. We also discuss the factors influencing the recovery and establishment of a new community structure following drug exposure. These survival strategies are key to the stability and resilience of the gut microbiome, ultimately influencing the overall health and well-being of the host.
人类相关微生物对药物暴露的生存策略主要在暴露于抗生素的真正病原体的背景下进行研究。对于非致病性微生物和宿主相关共生群落应对人类接触的各种药物和外源性化学物质的生存策略，了解得较少。在复杂的群落中，微生物共生体的生活方式为适应不同的药物诱导应激提供了多种方式。在这里，我们综述了肠道共生体在个体和群落水平上暴露于药物-抗生素和非抗生素时所采用的反应和生存策略。我们还讨论了影响药物暴露后恢复和建立新群落结构的因素。这些生存策略是肠道微生物组稳定性和弹性的关键，最终影响宿主的整体健康和福祉。
