Lan Cheng-Hang, Ou Lun-Chun, Liu Hung-Hsin, Peng Chiung-Yu
Department of Occupational Safety and Health, Chung-Hwa University of Medical Technology, Tainan, 71703, Taiwan.
Department of Public Health, College of Health Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd, Kaohsiung, 80708, Taiwan.
Sci Rep. 2024 Jun 13;14(1):13662. doi: 10.1038/s41598-024-64277-0.
The fabricated metal product industries were identified as producers of variable and heterogeneous pollution. Workers in these manufacturing facilities are exposed to multiple pollutants present at variable concentrations. Specific known adverse health effects include bladder cancer associated with metalworking fluid exposure and lung cancer associated with electroplating processes. To reduce the incidence of these adverse effects, the main challenge is to identify the most hazardous pollutants within this complex exposure environment and evaluate the corresponding health potentials. In this study, exposure indices were formulated to assess multiple metal exposures with the ultimate goal of providing relevant information for exposure reduction and control measures. Fifteen plants, including metal mold manufacturing, metal casting, and surface treatment plants, were investigated in terms of total concentration, summation of corresponding ratio to threshold limit value (STLV), hazard index (HI), and incremental cancer risk. The results revealed that emissions of aluminum, iron, and manganese were primarily found in the metal mold manufacturing/casting plants, while emissions of chromium, nickel, and zinc were found in surface treatment plants. STLV and HI were more useful than the total concentration for identifying hazardous metals, which were chromium and nickel, and could specify the facilities that were in need of control measures. As for cancer risk, the metal mold manufacturing/casting plants had lower risk than the surface treatment plants, and the contributing metals for these two plant types were cobalt and chromium, respectively. This study established a useful procedure to evaluate health hazards and cancer risk. The resulting information is useful for prioritizing mitigation control of multiple metal exposures.
金属制品制造业被认定为可变且异质污染的产生源。这些制造工厂的工人暴露于多种浓度各异的污染物中。已知的特定不良健康影响包括与金属加工液接触相关的膀胱癌以及与电镀工艺相关的肺癌。为降低这些不良影响的发生率,主要挑战在于在这种复杂的暴露环境中识别最具危害性的污染物,并评估相应的健康风险。在本研究中,制定了暴露指数以评估多种金属暴露情况,最终目标是为减少暴露和控制措施提供相关信息。对15家工厂进行了调查,包括金属模具制造、金属铸造和表面处理厂,调查内容涉及总浓度、与阈限值的相应比值总和(STLV)、危害指数(HI)和增量癌症风险。结果显示,铝、铁和锰的排放主要出现在金属模具制造/铸造厂,而铬、镍和锌的排放则出现在表面处理厂。对于识别有害金属(即铬和镍)而言,STLV和HI比总浓度更有用,并且可以确定需要采取控制措施的设施。至于癌症风险,金属模具制造/铸造厂的风险低于表面处理厂,这两种工厂类型的致癌金属分别是钴和铬。本研究建立了一个评估健康危害和癌症风险的有用程序。所得信息有助于对多种金属暴露的缓解控制进行优先排序。