Holmbeg L, Nilsson I M
Thromb Haemost. 1979 Oct 31;42(3):1033-8.
Thirty patients with various forms of von Willebrand's disease were investigated for VIIIR:Ag in their platelets. VIIIR:Ag was extracted from washed platelets and measured both with electroimmunoassay and a sensitive immunoradiometric assay. Six patients had severe von Willebrand's disease, type I, with very low or no VIIIR:Ag in their plasma. None of these patients had any VIIIR:Ag detectable in their platelets. All 19 patients with mild von Willebrand's disease had VIIIR:Ag in their platelets but the values often fell below those of normal controls. Five patients with genetic variants of von Willebrand's disease also had values in their platelets corresponding to those in plasma.
对30例不同类型血管性血友病患者的血小板进行了Ⅷ因子相关抗原（VIIIR:Ag）检测。从洗涤后的血小板中提取VIIIR:Ag，并用免疫电泳法和灵敏的免疫放射分析法定量测定。6例为重型血管性血友病Ⅰ型患者，其血浆中VIIIR:Ag极低或无。这些患者的血小板中均未检测到VIIIR:Ag。19例轻型血管性血友病患者的血小板中均有VIIIR:Ag，但数值常低于正常对照。5例血管性血友病基因变异型患者血小板中的数值与血浆中的数值相符。
