Molecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Exp Mol Med. 2024 Jun;56(6):1263-1271. doi: 10.1038/s12276-024-01266-3. Epub 2024 Jun 14.
MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in biological processes spanning from early developmental stages to the intricate process of aging. Extensive research has underscored the fundamental role of miRNAs in orchestrating eukaryotic development, with disruptions in miRNA biogenesis resulting in early lethality. Moreover, perturbations in miRNA function have been implicated in the aging process, particularly in model organisms such as nematodes and flies. miRNAs tend to be clustered in vertebrate genomes, finely modulating an array of biological pathways through clustering within a single transcript. Although extensive research of their developmental roles has been conducted, the potential implications of miRNA clusters in regulating aging remain largely unclear. In this review, we use the Mir-23-27-24 cluster as a paradigm, shedding light on the nuanced physiological functions of miRNA clusters during embryonic development and exploring their potential involvement in the aging process. Moreover, we advocate further research into the intricate interplay among miRNA clusters, particularly the Mir-23-27-24 cluster, in shaping the regulatory landscape of aging.
微小 RNA（miRNA）是基因表达的关键调控因子，参与从早期发育阶段到复杂的衰老过程等多种生物学过程。大量研究强调了 miRNA 在真核生物发育中的基本作用，miRNA 生物发生的中断会导致早期致死。此外，miRNA 功能的失调与衰老过程有关，特别是在线虫和苍蝇等模式生物中。miRNA 倾向于在脊椎动物基因组中聚类，通过在单个转录本内聚类来精细调节一系列生物学途径。尽管已经对其发育作用进行了广泛的研究，但 miRNA 簇在调节衰老中的潜在影响在很大程度上仍不清楚。在这篇综述中，我们以 Mir-23-27-24 簇为例，阐明了 miRNA 簇在胚胎发育过程中微妙的生理功能，并探讨了它们在衰老过程中的潜在作用。此外，我们主张进一步研究 miRNA 簇之间的复杂相互作用，特别是 Mir-23-27-24 簇，以塑造衰老的调控景观。
