Department of Drug Analysis and Pharmaceutical Technology, Faculty of Medicine, University of Prishtina, Kosovo; Technology Research Development Application and Research Center, Trakya University, Edirne; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens-University of Graz, Austria.
Technology Research Development Application and Research Center, Trakya University, Edirne.
Pharmazie. 2024 May 15;79(3):49-56. doi: 10.1691/ph.2024.3037.
Multidrug resistance, severe side effects, and high cancer treatment costs are still well-known issues and remain an open challenge. These factors reduce the therapy's efficiency and safety, seriously affecting human health. Developing therapeutic approaches based on plant extracts, especially based on essential oils with cytotoxic and antioxidant properties, could be of efficacious strategies. This work incorporated essential oil (TEO) in liposomes. is a plant native to the northern region of Albania and found specifically in the Mediterranean region. TEO has several biological activities and cytotoxic properties. Due to its volatility, poor solubility, and chemical instability, however, its applicability is restricted. Incorporation into liposomes enables its effective use because the exposure time to the active compounds can be extended, increasing its efficacy against colorectal cancer cell lines, as highlighted in studies. TEO demonstrated detectable cytotoxic action against HT-29 colorectal cancer cells, and this action could be enhanced by applying various formulations of TEO-loaded liposomes to this cell line. Among the tested nanosystems, TEO-Phospholipon 90H liposomes showed more significant cytotoxic effects than TEO-Lipoid S100 liposomes and TEO-Phospholipon 85G liposomes. TEO-Phospholipon 90 H liposomes also maintained its physicochemical stability for six months at 25 °C. This research suggests that TEO, particularly when encapsulated in TEO-Phospholipon 90 H liposomes, may offer a promising therapeutic approach. However, these findings are based on studies and further research is needed to validate the efficacy and safety of this approach in clinical settings.
多药耐药性、严重的副作用和高昂的癌症治疗费用仍然是众所周知的问题，也是一个亟待解决的挑战。这些因素降低了治疗的效率和安全性，严重影响了人类健康。基于植物提取物，特别是具有细胞毒性和抗氧化特性的精油，开发治疗方法可能是一种有效的策略。本工作将精油（TEO）包封于脂质体中。TEO 是一种原产于阿尔巴尼亚北部地区的植物，仅在地中海地区发现。TEO 具有多种生物活性和细胞毒性特性。然而，由于其挥发性、较差的溶解度和化学不稳定性，其适用性受到限制。将其包封于脂质体中可以有效利用，因为可以延长暴露于活性化合物的时间，从而提高其对结直肠癌细胞系的疗效，正如 研究中所强调的那样。TEO 对 HT-29 结直肠癌细胞表现出可检测的细胞毒性作用，通过将各种载有 TEO 的脂质体制剂应用于该细胞系，可以增强这种作用。在测试的纳米系统中，TEO-Phospholipon 90H 脂质体比 TEO-Lipoid S100 脂质体和 TEO-Phospholipon 85G 脂质体表现出更显著的细胞毒性作用。TEO-Phospholipon 90H 脂质体在 25°C 下也能保持其六个月的物理化学稳定性。本研究表明，TEO，特别是当封装在 TEO-Phospholipon 90H 脂质体中时，可能提供一种有前途的治疗方法。然而，这些发现基于 研究，需要进一步的 研究来验证这种方法在临床环境中的疗效和安全性。
