Faculty of Food Processing Techology, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Calea Aradului, No. 119, Timisoara 300645, Romania.
Faculty of Horticulture and Forestry, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Calea Aradului, No. 119, Timisoara 300645, Romania.
Molecules. 2018 Jan 16;23(1):185. doi: 10.3390/molecules23010185.
The current study aimed to investigate the chemical composition and the synergistic potential of two essential oils (EOs), as obtained from L. (SEO), and L. (TEO). The antifungal potential was tested in vitro against (Fg 06_17), the herbicidal effect was studied using weed seeds of (ARET), (CALB), (EGAL), but also wheat seeds (WS) of the Lovrin variety and tomato seeds Saint-Pierre of the variety. The GC-MS profile highlights that the mains compounds identified in SEO were: caryophyllene 25.364%), camphene (14.139%), eucalyptol (13.902%), and -pinene (11.230%), while in TEO, the predominant phytochemicals were: -terpinene (68.415%) and -thymol (24.721%). The results indicated that the tested EOs alone as well as in combination have allelopathic effect against investigated seeds, while the synergistic effect of TEO and SEO in terms of fungal growth was demonstrated at a level of 0.06%. Thyme and sage EOs exhibited in vitro anti-proliferative activity on two melanoma cell lines, namely A375 human melanoma and B164A5 mouse melanoma alone, as well as in combination. SEO was most effective in terms of decreasing the cell viability of murine and human melanoma cell lines when compared to TEO.
本研究旨在探讨两种精油（来自 和 ）的化学成分及其协同潜力。体外测试了它们对 的抗真菌潜力，研究了它们对野草种子（ARET、CALB、EGAL）、Lovrin 品种的小麦种子和 Saint-Pierre 品种的番茄种子的除草效果。GC-MS 图谱表明，SEO 中的主要化合物为：石竹烯（25.364%）、莰烯（14.139%）、桉油醇（13.902%）和 -蒎烯（11.230%），而 TEO 中的主要植物化学成分则为：-松油烯（68.415%）和 -百里酚（24.721%）。结果表明，测试的精油单独以及组合使用都对所研究的种子具有化感作用，而在真菌生长方面，百里香和鼠尾草精油显示出协同作用，其协同水平为 0.06%。百里香和鼠尾草精油在体外对两种黑色素瘤细胞系（人黑色素瘤 A375 细胞和鼠黑色素瘤 B164A5 细胞）以及它们的组合均具有抗增殖活性。与 TEO 相比，SEO 在降低鼠和人黑色素瘤细胞系的细胞活力方面更为有效。
