Zheng Yunyun, An Hangyi, Qi Jinxu, Li Jiaming
Medical School of Pingdingshan University, Pingdingshan, China.
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou, China.
Front Chem. 2024 May 30;12:1424022. doi: 10.3389/fchem.2024.1424022. eCollection 2024.
Mitochondria are the energy factories of cells and are important targets for the development of novel tumour treatment strategies owing to their involvement in processes such as apoptosis, oxidative stress, and metabolic programming. Thiosemicarbazone metal complexes target mitochondria and reduce mitochondrial membrane potential. The breakdown of mitochondrial membrane potential is a key event in the early stage of apoptosis, which releases cytochrome C and other pro-apoptotic factors, activates the intracellular apoptotic enzyme cascade, and eventually causes irreversible apoptosis of tumour cells. Thiosemicarbazone metal complexes targeting the mitochondria have recently emerged as potential antitumour agents; therefore, this review describes the structural diversity of thiosemicarbazone metal [Fe(III), Cu(II), Ni(II), Zn(II), Ga(III), Pb(II), Au(III), and Ir(III)] complexes and explores their anti-tumour mechanisms that target mitochondrial pathways.
线粒体是细胞的能量工厂，由于其参与细胞凋亡、氧化应激和代谢编程等过程，成为新型肿瘤治疗策略开发的重要靶点。硫代卡巴腙金属配合物靶向线粒体并降低线粒体膜电位。线粒体膜电位的破坏是细胞凋亡早期的关键事件，它释放细胞色素C和其他促凋亡因子，激活细胞内凋亡酶级联反应，最终导致肿瘤细胞发生不可逆的凋亡。靶向线粒体的硫代卡巴腙金属配合物最近已成为潜在的抗肿瘤药物；因此，本综述描述了硫代卡巴腙金属[铁（III）、铜（II）、镍（II）、锌（II）、镓（III）、铅（II）、金（III）和铱（III）]配合物的结构多样性，并探讨了它们靶向线粒体途径的抗肿瘤机制。
