Latarissa Irma Rahayu, Meiliana Anna, Sormin Ida Paulina, Sugiono Erizal, Wathoni Nasrul, Barliana Melisa Intan, Lestari Keri
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Prodia Clinical Laboratory, Jakarta, Indonesia.
Front Pharmacol. 2024 May 30;15:1383359. doi: 10.3389/fphar.2024.1383359. eCollection 2024.
In recent years, diverse initiatives have been carried out to control the COVID-19 pandemic, ranging from measures restricting social activities to analyzing drugs and vaccines. Studies on herbal medicines are also increasingly conducted in various countries as an adjuvant therapy or supplement. Therefore, this systematic review aimed to investigate the efficacy of herbal medicines analyzed from various countries through clinical trials with the randomized controlled trial method. The outcomes of Length of Stay (LOS), Negative Conversion Time (NCT), and Negative Conversion Rate (NCR) were the main focus.
An extensive review of literature spanning from 2019 to 2023 was carried out using well-known databases including PubMed, Scopus, and Cochrane. The search included relevant keywords such as "randomized controlled trial," "COVID-19," and "herbal medicine."
A total of 8 articles were part of the inclusion criteria with outcomes of LOS, NCT, and NCR. In terms of LOS outcomes, all types of herbal medicines showed significant results, such as Persian Medicine Herbal (PM Herbal), Persian Barley Water (PBW), Jingyin Granules (JY granules), Reduning Injection, and (Amla). However, only JY granules showed significant results in NCR outcome, while JY granules and Reduning Injection showed significant results in reducing NCT.
These findings enrich our understanding of the potential benefits of herbal medicines in influencing LOS, NCR and NCT parameters in COVID-19 patients. Herbal medicines worked to treat COVID-19 through antiviral, anti-inflammatory, and immunomodulatory mechanisms.
近年来，为控制新冠疫情开展了各种举措，从限制社交活动的措施到分析药物和疫苗。各国也越来越多地开展关于草药的研究，将其作为辅助治疗或补充剂。因此，本系统评价旨在通过随机对照试验方法进行的临床试验，研究各国分析的草药的疗效。主要关注住院时间（LOS）、病毒转阴时间（NCT）和病毒转阴率（NCR）等结果。
使用包括PubMed、Scopus和Cochrane在内的知名数据库，对2019年至2023年的文献进行了广泛回顾。搜索包括“随机对照试验”、“新冠病毒-19”和“草药”等相关关键词。
共有8篇文章符合纳入标准，涉及LOS、NCT和NCR结果。在LOS结果方面，所有类型的草药都显示出显著效果，如波斯医学草药（PM草药）、波斯大麦水（PBW）、荆银颗粒（JY颗粒）、热毒宁注射液和余甘子。然而，只有JY颗粒在NCR结果中显示出显著效果，而JY颗粒和热毒宁注射液在缩短NCT方面显示出显著效果。
这些发现丰富了我们对草药在影响新冠患者的LOS、NCR和NCT参数方面潜在益处的理解。草药通过抗病毒、抗炎和免疫调节机制来治疗新冠。
