Komariah Maria, Amirah Shakira, Maulana Sidik, Abdurrahman Muhammad Fahd, Ibrahim Kusman, Platini Hesti, Lele Juan Alessandro Jeremis Maruli Nura, Kohar Kelvin, Rahayuwati Laili, Firdaus Mohd Khairul Zul Hasymi
Department of Fundamental Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, Indonesia.
Undergraduate Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.
Ther Clin Risk Manag. 2023 Jul 18;19:611-627. doi: 10.2147/TCRM.S405507. eCollection 2023.
The COVID-19 pandemic continues, and this condition has caused many cases in various countries around the world, resulting in more than 6 million deaths worldwide. Herbal medicines can act as immunomodulators, anti-inflammatories, antioxidants, antimicrobials, and others depending on the type and content of the herbs used. Previous studies have shown that several types of herbs, such as , have proven their effectiveness as herbal plants for COVID-19.
We conducted a comprehensive literature search through five databases, namely, PubMed, Scopus, Embase, Wiley, and ProQuest to assess the efficacy of phytopharmaceuticals until July 12, 2022. We used the Cochrane RoB 2.0 for the quality assessment of the study.
Phytopharmaceuticals significantly improved patients' recovery rate (OR = 3.54; < 0.00001) and reduced deaths (OR = 0.24; < 0.0001) compared to the control group. Phytopharmaceuticals also performed as a protective factor for COVID-19 clinical symptoms, such as dyspnea (OR = 0.42; < 0.05) and myalgia (OR = 0.31; = 0.02) compared to the control group. However, there is no statistically significant effect on cough (OR = 0.76; = 0.61) and fever (OR = 0.60; < 0.20). The results were not affected by patients' covariates [hypertension, diabetes mellitus, and cardiovascular diseases (meta-regression > 0.05)].
Herbal medicine has the potential as an adjuvant therapy in the management of COVID-19.
新冠疫情仍在持续，全球各国出现了大量病例，导致全球死亡人数超过600万。草药可作为免疫调节剂、抗炎药、抗氧化剂、抗菌剂等，具体取决于所使用草药的种类和成分。此前的研究表明，几种草药，如 ，已证明其作为治疗新冠的草药的有效性。
我们通过五个数据库进行了全面的文献检索，即PubMed、Scopus、Embase、Wiley和ProQuest，以评估截至2022年7月12日植物药的疗效。我们使用Cochrane RoB 2.0对研究进行质量评估。
与对照组相比，植物药显著提高了患者的康复率（OR = 3.54；< 0.00001）并降低了死亡率（OR = 0.24；< 0.0001）。与对照组相比，植物药还对新冠临床症状起到保护作用，如呼吸困难（OR = 0.42；< 0.05）和肌痛（OR = 0.31；= 0.02）。然而，对咳嗽（OR = 0.76；= 0.61）和发热（OR = 0.60；< 0.20）没有统计学上的显著影响。结果不受患者协变量[高血压、糖尿病和心血管疾病（meta回归> 0.05）]的影响。
草药有潜力作为新冠治疗的辅助疗法。
