Metabolic effects of conversion from cyclosporine to azathioprine in renal transplant recipients.

The metabolic effects of conversion from cyclosporine (Cys) to azathioprine were studied in 10 non-diabetic renal transplant recipients. Following conversion there was a significant improvement in renal function. There was no evidence of glucose intolerance pre-conversion, and no change in glucose metabolism following conversion. However, fasting cholesterol and triglyceride levels were significantly improved following conversion. The mechanism of this change and its significance needs further investigation.