Department of Physiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Department of Internal Medicine, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Int J Rheum Dis. 2024 Jun;27(6):e15216. doi: 10.1111/1756-185X.15216.
To determine whether the IG count (#) and IG percentage (%) are associated with disease activity in rheumatoid arthritis (RA).
This retrospective study included 65 RA patients and 65 healthy controls. Clinical and demographic characteristics of controls and RA patients (at active period and when the patients achieved remission) were obtained from medical records. Disease activity was defined by disease activity score 28 (DAS28). Furthermore, the clinical disease activity index (CDAI), and simple disease activity index (SDAI) were calculated. For the differential diagnosis of RA patients from healthy controls, the cut-off value was estimated by making receiver-operator curves (ROC).
In active RA patients, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), IG#, and IG% levels were significantly higher compared to the healthy controls (p < .001, for all). When the patients achieved remission, DAS28, CDAI, SDAI, ESR, CRP, IG#, and IG% values were significantly decreased (p < .001, for all). IG# and IG% were significantly positively correlated with DAS28, CDAI, SDAI, ESR, and CRP (p = .024, p = .008, p = .003, p < .001, p < .001, respectively). According to ROC curve analysis, IG% and IG# were the biomarkers to have a significant diagnostic value for RA with the area under the curve of 0.853 and 0.865 (p < .001, for all).
The present study demonstrated that two novel inflammatory markers, IG# and IG%, can be useful for monitoring RA patients' disease activity. Furthermore, IG# and IG% can also be used as fast, inexpensive, and easily available complementary diagnostic markers to diagnose RA patients.
确定免疫球蛋白（IG）计数（#）和百分比（%）是否与类风湿关节炎（RA）的疾病活动度相关。
本回顾性研究纳入了 65 例 RA 患者和 65 名健康对照者。从病历中获取对照者和 RA 患者（活动期和缓解期）的临床和人口统计学特征。疾病活动度由 28 个关节疾病活动度评分（DAS28）定义。此外，还计算了临床疾病活动指数（CDAI）和简化疾病活动指数（SDAI）。为了将 RA 患者与健康对照者进行鉴别诊断，通过制作受试者工作特征曲线（ROC）来估计截断值。
在活动期 RA 患者中，红细胞沉降率（ESR）、C 反应蛋白（CRP）、IG#和 IG%水平明显高于健康对照者（p<0.001，均为）。当患者达到缓解时，DAS28、CDAI、SDAI、ESR、CRP、IG#和 IG%值均显著降低（p<0.001，均为）。IG#和 IG%与 DAS28、CDAI、SDAI、ESR 和 CRP 呈显著正相关（p=0.024，p=0.008，p=0.003，p<0.001，p<0.001，分别为）。根据 ROC 曲线分析，IG%和 IG#是 RA 具有显著诊断价值的生物标志物，曲线下面积分别为 0.853 和 0.865（p<0.001，均为）。
本研究表明，两种新型炎症标志物 IG#和 IG%可用于监测 RA 患者的疾病活动度。此外，IG#和 IG%也可作为快速、经济且易于获得的补充诊断标志物，用于诊断 RA 患者。
