Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, Republic of Korea.
Rheumatol Int. 2012 Feb;32(2):545-9. doi: 10.1007/s00296-011-1798-x. Epub 2011 Feb 9.
The aim of this study is to examine the validity of the rheumatoid arthritis (RA), disease activity score (DAS), 28-C-reactive protein (CRP), the simplified disease activity index (SDAI), and the clinical disease activity index (CDAI) against the DAS28-erythrocyte sedimentation rate (ESR) and determine cut-off values for each tool in Korean patients with RA. A total of 223 RA patients were consecutively recruited from the Hanyang University Hospital for Rheumatic Diseases in Seoul, Korea. DAS28-CRP, SDAI, and CDAI were measured and compared with DAS28-ESR. The correlation coefficients of DAS28-ESR with DAS28-CRP, SDAI, and CDAI were 0.93, 0.85, and 0.84, demonstrating strong linear relationships. The cut-off values of DAS28-CRP classifying RA patients into four categories of disease activity were defined as 2.19, 2.60, and 4.07. SDAI cut-off values were defined as 3.75, 7.50, and 16.88. CDAI cut-off values were defined as 3.62, 7.38, and 16.50. DAS28-CRP, SDAI, and CDAI are valid and sensitive assessment indices of disease activity that are comparable to DAS28-ESR. The cut-off values of each tool derived in this study might be useful for routine monitoring and therapeutic decision-making in Korean RA patients.
本研究旨在检验类风湿关节炎（RA）、疾病活动评分（DAS）、28- 反应蛋白（CRP）、简化疾病活动指数（SDAI）和临床疾病活动指数（CDAI）对于 DAS28-红细胞沉降率（ESR）的有效性，并确定每个工具在韩国 RA 患者中的截断值。本研究共连续招募了 223 例来自韩国首尔汉扬大学风湿病医院的 RA 患者。测量并比较了 DAS28-CRP、SDAI 和 CDAI 与 DAS28-ESR 的相关性。DAS28-ESR 与 DAS28-CRP、SDAI 和 CDAI 的相关系数分别为 0.93、0.85 和 0.84，表明存在很强的线性关系。将 DAS28-CRP 分类为四个疾病活动类别的截断值定义为 2.19、2.60 和 4.07。SDAI 的截断值定义为 3.75、7.50 和 16.88。CDAI 的截断值定义为 3.62、7.38 和 16.50。DAS28-CRP、SDAI 和 CDAI 是评估疾病活动的有效且敏感的指标，与 DAS28-ESR 相当。本研究中得出的每个工具的截断值可能对韩国 RA 患者的常规监测和治疗决策有用。
