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Using Sex-Specific Polygenic Risk to Prognosticate Coronary Artery Disease in Women.

作者信息

Paruchuri Kaavya, Bhukar Rohan, Urbut Sarah, Ruan Yunfeng, Ganesh Shriienidhie, Postupaka Darina, Natarajan Pradeep

机构信息

Cardiovascular Research Center Massachusetts General Hospital Boston MA.

Program in Medical and Population Genetics and Cardiovascular Disease Initiative Broad Institute of Harvard and MIT Cambridge MA.

出版信息

J Am Heart Assoc. 2024 Jun 18;13(12):e034946. doi: 10.1161/JAHA.123.034946. Epub 2024 Jun 14.

DOI:10.1161/JAHA.123.034946
PMID:38874071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11255742/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c288/11255742/3d0d17e90551/JAH3-13-e034946-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c288/11255742/3d0d17e90551/JAH3-13-e034946-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c288/11255742/3d0d17e90551/JAH3-13-e034946-g001.jpg

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本文引用的文献

1
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.多血统多基因风险评分可提高冠心病风险预测。
Nat Med. 2023 Jul;29(7):1793-1803. doi: 10.1038/s41591-023-02429-x. Epub 2023 Jul 6.
2
Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction.性别特异性生存偏差与冠状动脉疾病风险预测中的交互作用建模。
Circ Genom Precis Med. 2023 Feb;16(1):e003542. doi: 10.1161/CIRCGEN.121.003542. Epub 2022 Dec 29.
3
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
在超过 100 万名参与者中发现并系统地描述了冠心病的风险变异和基因。
Nat Genet. 2022 Dec;54(12):1803-1815. doi: 10.1038/s41588-022-01233-6. Epub 2022 Dec 6.
4
Genetic analyses identify widespread sex-differential participation bias.遗传分析确定了广泛存在的性别差异参与偏见。
Nat Genet. 2021 May;53(5):663-671. doi: 10.1038/s41588-021-00846-7. Epub 2021 Apr 22.
5
The impact of sex on gene expression across human tissues.性别对人类组织中基因表达的影响。
Science. 2020 Sep 11;369(6509). doi: 10.1126/science.aba3066.