Makerere University, Kampala, Uganda.
Infectious Diseases Research Collaboration, Kampala, Uganda.
J Infect Dis. 2024 Aug 16;230(2):497-504. doi: 10.1093/infdis/jiae288.
Newly arrived refugees offer insights into malaria epidemiology in their countries of origin. We evaluated asymptomatic refugee children within 7 days of arrival in Uganda from South Sudan and the Democratic Republic of Congo (DRC) in 2022 for parasitemia, parasite species, and Plasmodium falciparum drug resistance markers. Asymptomatic P. falciparum infections were common in both populations. Coinfection with P. malariae was more common in DRC refugees. Prevalences of markers of aminoquinoline resistance (PfCRT K76T, PfMDR1 N86Y) were much higher in South Sudan refugees, of antifolate resistance (PfDHFR C59R and I164L, PfDHPS A437G, K540E, and A581G) much higher in DRC refugees, and of artemisinin partial resistance (ART-R; PfK13 C469Y and A675V) moderate in both populations. Prevalences of most mutations differed from those seen in Ugandans attending health centers near the refugee centers. Refugee evaluations yielded insights into varied malaria epidemiology and identified markers of ART-R in 2 previously little-studied countries.
新到达的难民提供了有关其原籍国疟疾流行病学的见解。我们评估了 2022 年在乌干达从南苏丹和刚果民主共和国（DRC）新抵达的无症状难民儿童的寄生虫血症、寄生虫种类和恶性疟原虫抗药性标志物。在这两个群体中，无症状恶性疟原虫感染都很常见。在 DRC 难民中，疟原虫疟原虫与疟原虫疟原虫的合并感染更为常见。在南苏丹难民中，抗疟喹啉耐药性标志物（PfCRT K76T、PfMDR1 N86Y）的流行率要高得多，在 DRC 难民中，抗叶酸耐药性标志物（PfDHFR C59R 和 I164L、PfDHPS A437G、K540E 和 A581G）的流行率要高得多，而青蒿素部分耐药性（ART-R；PfK13 C469Y 和 A675V）在两个群体中均为中度。大多数突变的流行率与在难民中心附近的卫生中心就诊的乌干达人不同。难民评估提供了对不同疟疾流行病学的见解，并在两个以前研究较少的国家发现了抗青蒿素药物耐药性的标志物。
