Correction to 'hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling'.
出版信息
Nucleic Acids Res. 2024 Jul 22;52(13):8034. doi: 10.1093/nar/gkae525.
Abstract
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1
Correction to 'hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling'.对“hnRNPA1耦合FGF-2/S6K2信号下游特定mRNA的核输出与翻译”的修正
Nucleic Acids Res. 2024 Jul 22;52(13):8034. doi: 10.1093/nar/gkae525.
2
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.异质性核糖核蛋白A1（hnRNPA1）将成纤维细胞生长因子-2（FGF-2）/核糖体蛋白S6激酶2（S6K2）信号下游特定信使核糖核酸（mRNA）的核输出与翻译联系起来。
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Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.雷帕霉素作用的哺乳动物靶点对核糖体S6激酶2的调控
J Biol Chem. 2002 Aug 30;277(35):31423-9. doi: 10.1074/jbc.M204080200. Epub 2002 Jun 26.
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Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer.S6K2介导的hnRNPA1中Ser6的磷酸化调控结直肠癌的葡萄糖代谢和细胞生长。
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Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.肿瘤抑制因子 PDCD4 抑制抗凋亡蛋白的内部核糖体进入位点介导的翻译，并且受到 S6 激酶 2 的调控。
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S6K2 promises an important therapeutic potential for cancer.S6K2 有望成为癌症治疗的重要靶点。
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Identification of the general transcription factor Yin Yang 1 as a novel and specific binding partner for S6 kinase 2.鉴定通用转录因子 Yin Yang 1 为 S6 激酶 2 的一种新型且特异性的结合伴侣。
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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.S6K1基因敲除/S6K2基因敲除小鼠表现出围产期致死性以及对雷帕霉素敏感的5'-末端寡嘧啶mRNA翻译，并揭示了一条丝裂原活化蛋白激酶依赖性S6激酶途径。
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FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.成纤维细胞生长因子-2通过一个涉及蛋白激酶Cε、B-Raf和S6K2的复合体保护小细胞肺癌细胞免于凋亡。
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