迷走神经完整性在胃泌素释放肽刺激胃肠胰激素释放及胃酸分泌中的作用

The role of vagal integrity in gastrin releasing peptide stimulated gastroenteropancreatic hormone release and gastric acid secretion.

作者信息

Greenberg G R, Chan B, McDonald T J, Alleyne J

出版信息

Regul Pept. 1985 Mar;10(2-3):179-87. doi: 10.1016/0167-0115(85)90012-6.

Abstract

The role of the vagus nerve in the control of gastrin releasing peptide (GRP) stimulated gastroenteropancreatic hormone release and gastric acid secretion was investigated in four conscious gastric fistula dogs using a technique of bilateral cryogenic vagal blockade. A 90-min infusion of GRP at a dose of 400 pmol X kg-1. h-1 produced significant elevations in plasma levels of gastrin, motilin, GIP, enteroglucagon, insulin, pancreatic glucagon, pancreatic polypeptide and VIP. Vagal blockade reversibly inhibited the rise of plasma PP and significantly blunted the elevation of plasma VIP. However, the GRP stimulated response of the other hormones investigated was not modified by vagal blockade. Similarly, the substantial secretion of gastric acid observed with GRP was not influenced by vagal blockade. Thus GRP acts predominantly via mechanisms which are independent of vagal integrity, findings that are in support of a major role for the local neuromodulation of hormone release and gastric acid secretion.

摘要

采用双侧低温迷走神经阻断技术，在4只清醒胃瘘犬中研究了迷走神经在胃泌素释放肽（GRP）刺激胃肠胰激素释放和胃酸分泌控制中的作用。以400 pmol·kg⁻¹·h⁻¹的剂量输注GRP 90分钟，可使胃泌素、胃动素、葡萄糖依赖性促胰岛素多肽、肠高血糖素、胰岛素、胰高血糖素、胰多肽和血管活性肠肽的血浆水平显著升高。迷走神经阻断可可逆性抑制血浆胰多肽的升高，并显著减弱血浆血管活性肠肽的升高。然而，迷走神经阻断并未改变所研究的其他激素对GRP的刺激反应。同样，GRP引起的大量胃酸分泌也不受迷走神经阻断的影响。因此，GRP主要通过独立于迷走神经完整性的机制发挥作用，这一发现支持了局部神经调节在激素释放和胃酸分泌中起主要作用的观点。